A fitness-independent family of simultaneous amplifiers beyond relative fitness 3/2
We study fixation from a uniformly random single mutant on finite connected loopless undirected weighted graphs under both Birth–death (Bd) and death–Birth (dB) Moran updating. Let R_sim be the supremum of R for which one fitness-independent graph family eventually amplifies fixation under both rules for every fixed r in (1,R). Let R_hyb be
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MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Simultaneous removal of phosphate and fluoride by calcium peroxide in a binary system: performance and mechanisms. [PDF]
RSC AdvHu Q, Ma S, Yang X, Zhao X.
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
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Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Video reconstruction of variable VLBI observations with neural fields. [PDF]
NatureFoschi M +5 more
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Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
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Automated Workflow for Ion-Selective Electrodes via Mixed-Ion Inference. [PDF]
Sens Actuators B ChemDagar M, Pope TD, Sarolia U, Ren H.
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FEBS Open Bio, EarlyView.Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page +4 more
wiley +1 more source
Spatial-temporal and physical constrained deep learning model for simultaneous T1 and T2 reconstruction and mapping (STEP). [PDF]
Quant Imaging Med SurgYang R, Sun H, Lin X, Li H, Chen H.
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