Results 201 to 210 of about 475,022 (324)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Simultaneous film thickness and refractive index measurement using a constrained fitting method in a white light spectral interferometer

, 2021
Lin Yuan, Tong Guo, Dawei Tang, Haitao Liu, Xinyuan Guo   +4 more
openalex   +1 more source

Quenching Single-Fluorophore Systems and the Emergence of Nonlinear Stern-Volmer Plots. [PDF]

ACS Omega
Zangi R.
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Investigations into linker effects of DNA-VHL ligand conjugates by multiplexed affinity measurements using focal molography. [PDF]

RSC Chem Biol
Raschke P, Notova S, Gatterdam V, Frutiger A, Brunschweiger A.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Constraining the AGN tori at cosmic noon using high-resolution JWST imaging and simultaneous SED fitting [PDF]

Devang H. Liya, D. J. Rosario, Matthaios Charidis   +2 more
openalex   +1 more source

Simultaneous measurement of water transport across the blood-brain and blood-CSF barrier in the human brain with arterial spin labeling MRI. [PDF]

J Cereb Blood Flow Metab
Petitclerc L, Durrant H, Hirschler L, Václavů L, van Osch MJP.   +4 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Early tone perception ability in Mandarin-speaking children with simultaneous bilateral cochlear implants 24 months post-operatively. [PDF]

Sci Prog
Wang S, Tian X, Yang H, Shang Y, Wang B, Guo B, Yang J, Sun W, Zuo J, Lan Y, Gao Z.   +10 more
europepmc   +1 more source