Metabolic stress induces insulin resistance and upregulates PTP1B in granulosa cells, leading to aging‐relevant ovarian dysfunction. Gengnianchun (GNC) suppresses PTP1B, restores IRS1–AKT2–GLUT4 signaling, and preserves follicles, highlighting PTP1B as a therapeutic target for ovarian dysfunction in metabolically vulnerable states.
Yanqiu Rao +6 more
wiley +1 more source
ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet mice. [PDF]
Du T +17 more
europepmc +1 more source
ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major cause of cancer‐related mortality. Increasing evidence suggests that aberrant RNA metabolism contributes to tumour initiation, progression and therapeutic resistance.
Fandong Kong +6 more
wiley +1 more source
Enhanced Enzyme Cascade Reactions Through Coencapsulation in Biocompatible Silica Nanoconfinement
We coencapsulated glucose oxidase (GOX) and horseradish peroxidase (HRP) within silica nanoconfinement using an enzyme‐friendly synthesis method. The coencapsulated system demonstrated faster cascade kinetics than spatially separated configurations, providing direct evidence for beneficial proximity effects on intermediate transfer.
Ji‐Soo Lee +10 more
wiley +1 more source
On sampling series based on some combinations of sinc functions
Kivinukk, Andi, Tamberg, Gert
openaire +2 more sources
HELLS Reduction Contributes to Compressive Force-Induced Functional Changes in PDLSCs. [PDF]
Wang M, Li Q, Chen J, Han B, Hu W.
europepmc +1 more source
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer. [PDF]
Shao C +14 more
europepmc +1 more source
Resonance Energy Transfer-Driven Photothermal Nanoagent Enables Melanoma Ablation Under Low-Power Near-Infrared Irradiation. [PDF]
Singh P +16 more
europepmc +1 more source
Hybrid ray-tracing-QuaDRiGa/FDTD method for realistic 28 GHz exposure with 6G CF-MaMIMO in 3D outdoor environments. [PDF]
Wydaeghe R +5 more
europepmc +1 more source

