Results 171 to 180 of about 12,685 (261)

Protein Tyrosine Phosphatase 1B‐Mediated Granulosa Cell Insulin Resistance Links Metabolic Stress to Aging‐Relevant Ovarian Dysfunction and Is Reversed by Gengnianchun

Aging Cell, Volume 25, Issue 6, June 2026.
Metabolic stress induces insulin resistance and upregulates PTP1B in granulosa cells, leading to aging‐relevant ovarian dysfunction. Gengnianchun (GNC) suppresses PTP1B, restores IRS1–AKT2–GLUT4 signaling, and preserves follicles, highlighting PTP1B as a therapeutic target for ovarian dysfunction in metabolically vulnerable states.
Yanqiu Rao, Ting Xu, Yan Ding, Jun Li, Lingyun Gao, Yun Wang, Wenjun Wang   +6 more
wiley   +1 more source

Effects of SOX10 on the proliferative, invasive, migratory, and epithelial-mesenchymal transition abilities of triple-negative breast cancer cells. [PDF]

Front Oncol
Wang S, Jin L.
europepmc   +1 more source

RNA Metabolism Genes as Prognostic Biomarkers and Therapeutic Targets in Colorectal Cancer Based on the Analysis of Single‐Cell and Bulk‐RNA Sequencing Data

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major cause of cancer‐related mortality. Increasing evidence suggests that aberrant RNA metabolism contributes to tumour initiation, progression and therapeutic resistance.
Fandong Kong, Xuewei Zhang, Shuguang Su, Feilong Chen, Qiantao Ye, Ronghua Yang, Hanpeng Du   +6 more
wiley   +1 more source

ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet mice. [PDF]

Cell Mol Life Sci
Du T, Yao L, Wang W, Li Z, Dong J, Zhou Z, Shi C, Ge X, Ma R, Chen L, Xiang Y, He Z, Zheng L, Xu Y, Cao C, Jing J, Ma J, Yao B.   +17 more
europepmc   +1 more source

Enhanced Enzyme Cascade Reactions Through Coencapsulation in Biocompatible Silica Nanoconfinement

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
We coencapsulated glucose oxidase (GOX) and horseradish peroxidase (HRP) within silica nanoconfinement using an enzyme‐friendly synthesis method. The coencapsulated system demonstrated faster cascade kinetics than spatially separated configurations, providing direct evidence for beneficial proximity effects on intermediate transfer.
Ji‐Soo Lee, Da‐Hye Ryu, Myung Kyung Jung, Dong‐Hyun You, So‐Hee Park, Dae Youn Hwang, Beum‐Soo An, Seung Yun Yang, Sungbaek Seo, Youngwoo Choi, Seong‐Min Jo   +10 more
wiley   +1 more source

IER3 as an RFX5 transcriptional co-activator promotes hepatocellular carcinoma progression via AKR1B10-mediated p53 transcriptional regulation. [PDF]

Discov Oncol
Chen X, Zhang Q, Zhang N.
europepmc   +1 more source

Notch Signaling Is Associated with LED Light-Regulated Papilla Regeneration in the Sea Cucumber (<i>Apostichopus japonicus</i>). [PDF]

Int J Mol Sci
Cui D, Wang Y, Xia J, Dou Y, Sun J, Chang Y.   +5 more
europepmc   +1 more source

HELLS Reduction Contributes to Compressive Force-Induced Functional Changes in PDLSCs. [PDF]

Int J Mol Sci
Wang M, Li Q, Chen J, Han B, Hu W.
europepmc   +1 more source

MBD2 suppresses SFRP1 expression and promotes colorectal cancer development by blocking MED19 binding to its methylated promoter. [PDF]

Cancer Biol Ther
Huang X, Luo T, Ke L, Guan S, Wu H, Li B, Liu Y, Qi J.   +7 more
europepmc   +1 more source

Efficient Interleaved Multi-Band Outer Volume Suppression for Highly Accelerated Simultaneous Multi-Slice Imaging of the Heart. [PDF]

Bioengineering (Basel)
Arami A, Demirel OB, Kilic T, Moeller S, Zhao Y, Zhang Y, Tao Q, Lamb HJ, Akçakaya M, Weingärtner S.   +9 more
europepmc   +1 more source