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Normal Gallbladder Ejection Fraction Occurring Unexpectedly Obviates Need for Sincalide Stimulation

open access: yesClinical Nuclear Medicine, 2017
A 25-year-old man was referred for chronic right upper quadrant abdominal pain for hepatobiliary scintigraphy to evaluate the gallbladder (GB) function. An unexpected GB contraction with ejection fraction (EF) of 90% was observed during the first hour of baseline imaging. Subsequent stimulation with sincalide produced GB EF of 99%.
Samir, Hadi, Mark, Tulchinsky
openaire   +3 more sources
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Kinevac (Sincalide for Injection)/Squibb Diagnostics

Gastroenterology Nursing, 1991
Sincalide is a rapid-acting, synthetic analog of cholecystokinin for intravenous use in postevacuation cholecystography. Serious reactions to sincalide have not been reported. The intravenous administration of sincalide causes a prompt contraction of the gallbladder as compared to the stimulus of a fatty meal which causes progressive contraction that ...
Kathleen A Maher
exaly   +3 more sources

Pharmacological manipulation of sincalide (CCK-8)-induced suppression of feeding

Peptides, 1983
The current study involves an investigation of the possible neurotransmitter systems involved in the ability of exogenously administered sincalide (cholecystokinin octapeptide, CCK-8) to suppress feeding. Male rats previously trained to obtain food either during a daily 3-hr session, or conditioned to obtain food pellets on a fixed-ratio or fixed ...
Marvin C Wilson, John A Bedford
exaly   +3 more sources

Compounded Versus Proprietary Sincalide for Evaluation of Gallbladder Ejection Fraction

Annals of Pharmacotherapy, 2004
OBJECTIVE To report a comparison of compounded and proprietary sincalide in the evaluation of gallbladder ejection fraction during hepatobiliary scintigraphy. CASE SUMMARIES Two patients were referred to nuclear medicine with symptoms ...
Daniel T, Guarasci   +3 more
exaly   +3 more sources

Sincalide: A Cholecystokinin Agonist as an Aid in Endoscopic Retrograde Cholangiopancreatography-A Prospective Assessment

Journal of Clinical Gastroenterology, 1997
Although several approaches to overcome difficult bile duct cannulation and gain free biliary access have been popularized, the use of gastrointestinal peptide hormonal agents such as sincalide, a cholecystokinin agonist, as an alternative method has not been evaluated.
Allan P Weston
exaly   +3 more sources

Comparison of intravenous and intramuscular sincalide (C-terminal octapeptide of cholecystokinin) on gallbladder contraction in man

Digestive Diseases and Sciences, 1981
The effects of intramuscular and intravenous sincalide on gallbladder contraction and visualization of the bile ducts were compared in a group of 37 subjects referred for oral cholecystography. The maximum reduction in gallbladder size observed after sincalide 400 ng/kg intramuscular, 54.7 +/- 7.2% (mean +/- SEM), occurred 25 min after injection and ...
D E Wilson, Donald E Wilson
exaly   +3 more sources

Effect of Atropine and Sincalide on the Intestinal Uptake of F-18 Fluorodeoxyglucose

Clinical Nuclear Medicine, 1999
Variable diffuse intestinal uptake of F-18 fluorodeoxyglucose (FDG) is commonly seen in patients undergoing positron emission tomography (PET) imaging. Diffuse high uptake can obscure a lesion, whereas occasional high focal uptake can mimic a lesion. The cause of intestinal FDG uptake and the parameters that influence the level of uptake are unknown.We
, George M Segall, G M Segall
exaly   +3 more sources

Sincalide Cholescintigraphy—32 Years Later: Evidence-Based Data on Its Clinical Utility and Infusion Methodology

Seminars in Nuclear Medicine, 2012
Sincalide cholescintigraphy was first reported to have clinical utility in 1980. Since then, many publications have found that a reduced gallbladder ejection fraction (GBEF) can confirm the clinical diagnosis of acalculous chronic gallbladder disease and predict symptomatic relief with cholecystectomy.
Harvey A Ziessman
exaly   +3 more sources

CAN SINCALIDE CHOLESCINTIGRAPHY FULFIL THE ROLE OF A GALL‐BLADDER STRESS TEST FOR PATIENTS WITH GALL‐BLADDER STONES?

ANZ Journal of Surgery, 1998
Background:Patients referred to general surgeons for the treatment of gall‐bladder stones were studied to evaluate the role of sincalide cholescintigraphy as a gall‐bladder stress test in an effort to identify a group of patients whose pain was non‐biliary in origin and who would not be improved by cholecystectomy.Methods:Ten asymptomatic controls and ...
exaly   +3 more sources

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