Results 241 to 250 of about 2,277,000 (297)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Tidal tomography reveals a thermal anomaly beneath Mars's crustal dichotomy. [PDF]

Nature
Berne A, Wagner N, Matsuyama I, Goossens S, Genova A, Rovira-Navarro M, Bagheri A, Qin C, Marusiak A, Hemingway D, Lau HCP, Cheng KW, Zhong S, Nimmo F.   +13 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

NLCD: A method to discover nonlinear causal relations among genes. [PDF]

PLoS Comput Biol
Easwar A, Narayanan M.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Plasmodium falciparum sporozoite loads in Anopheles gambiae s.l. across agro-ecological zones of Benin: a cross-sectional field study. [PDF]

Trop Med Health
Akpodji S, Agbangla C, Affolabi ZK, Koukpo CZ, Tokponnon F, Osse R, Adjottin B, Ahouandjinou MJ, Odjo EM, Sominahouin A, Oussou O, Koumodji KD, Hougbé SZ, Yovogan B, Adoha C, Padonou GG, Akogbéto M.   +16 more
europepmc   +1 more source

Optimizing Transcutaneous Electrical Stimulation Based on Frequency-Dependent Tissue Modeling and Signal Analysis. [PDF]

Bioengineering (Basel)
Wu W, Tang J, Wang Q, Yang J.
europepmc   +1 more source

Hot Deformation Behavior of AA3102 Aluminum Alloy: Constitutive Modeling, Microstructural Evolution and Numerical Simulation. [PDF]

Materials (Basel)
Liu X, Jamadon NH, Liu X, Wei D, Jin C, Tang R, Zheng L, Liu C, Jiang L, Liu Z.   +9 more
europepmc   +1 more source

Chaos Detection in Noisy Signals Using Refined Signal Representations. [PDF]

Sensors (Basel)
Harężlak K, Augustyn DR, Josiński H, Świtoński A, Kasprowski P, Szczęsna A.   +5 more
europepmc   +1 more source