Results 11 to 20 of about 3,537,137 (199)

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

Clinical and Translational Medicine, 2022
Background The number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear.
Yang‐Yang Wang, En‐Qiang Chang, Rui‐Lou Zhu, Xiao‐Zhuan Liu, Guang‐Zhi Wang, Ning‐Tao Li, Wei Zhang, Jun Zhou, Xiang‐Dong Wang, Ming‐Yang Sun, Jia‐Qiang Zhang   +10 more
doaj   +1 more source

Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

Nature Communications, 2023
Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro, David M. Rutkowski, Kelli Ann Lynch, Ying Liu, Dimitrios Vavylonis, Naoki Watanabe   +5 more
doaj   +1 more source

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

eLife, 2022
Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz, Aaron R Hall, Eiji Usukura, Sawako Yamashiro, Naoki Watanabe, Dimitrios Vavylonis   +5 more
doaj   +1 more source

The inhibition of chloride intracellular channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells

Experimental and Molecular Medicine, 2019
Cancer: chloride transport protein protects tumors A chloride channel, a membrane protein involved in chloride transport, indirectly regulates calcium signaling to protect cancer cells from free radicals and DNA damage.
Jae-Rin Lee, Jong-Yoon Lee, Hyun-Ji Kim, Myong-Joon Hahn, Jong-Sun Kang, Hana Cho   +5 more
doaj   +1 more source

Genome-wide identification of nitrate transporter genes from Spirodela polyrhiza and characterization of SpNRT1.1 function in plant development

Frontiers in Plant Science, 2022
Nitrate transporter (NRT) genes that participate in nitrate transport and distribution are indispensable for plant growth, development, and stress tolerance.
Mengli Lv, Tiantian Dong, Jin Wang, Kaijing Zuo   +3 more
doaj   +1 more source

The role of urinary pteridines as disease biomarkers

Pteridines, 2017
Pteridines and their derivatives function as intermediates in the metabolism of several vitamins and cofactors, and their relevance to disease has inspired new efforts to study their roles as disease biomarkers.
Burton Casey, Ma Yinfa
doaj   +1 more source

Variations in Cell Surfaces of Estrogen Treated Breast Cancer Cells Detected by A Combined Instrument for Far-Field and Near-Field Microscopy

Analytical Cellular Pathology, 2002
The response of single breast cancer cells (cell line T‐47D) to 17β‐estradiol (E2) under different concentrations was studied by using an instrument that allows to combine far‐field light microscopy with high resolution scanning near‐field (AFM/SNOM ...
P. Perner, A. Rapp, C. Dressler, L. Wollweber, J. Beuthan, K. O. Greulich, M. Hausmann   +6 more
doaj   +1 more source

Protocol to generate fast-dissociating recombinant antibody fragments for multiplexed super-resolution microscopy

STAR Protocols, 2023
Summary: Multiplexed high-density label super-resolution microscopy image reconstruction by integrating exchangeable single-molecule localization (IRIS) enables elucidating fine structures and molecular distribution in cells and tissues.
Qianli Zhang, Akitoshi Miyamoto, Naoki Watanabe   +2 more
doaj   +1 more source

Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity

Journal for ImmunoTherapy of Cancer, 2023
Background Antineoplastic chemotherapies are dramatically efficient when they provoke immunogenic cell death (ICD), thus inducing an antitumor immune response and even tumor elimination.
Hui Wang, Mayu Sun, Xiaoguang Li, Jingquan Li, Jingyang Li, Huiyi Chen, Xiaoyu Han, Weida Li, Guanghuan Yang, Bao Guo   +9 more
doaj   +1 more source

Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features

Nature Communications
Cancer arises from genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To chart cancer-intrinsic regulatory programs, we build a pan-cancer single-cell atlas of 60 cancer cell lines spanning ...
Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao   +8 more
doaj   +1 more source