Results 21 to 30 of about 3,537,137 (199)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models

Genome Biology
The 10 × Genomics Flex Gene Expression protocol is a probe-based method that profiles fixed or frozen material, simplifying sample handling before scRNA-seq.
Oriol Llorà-Batlle, Anca Farcas, Doreth Fransen, Nicolas Floc’h, Sara Talbot, Alix Schwiening, Laura Bojko, John Calver, Natasa Josipovic, Kanstantsin Lashuk, Julia Schueler, Andrei Prodan, Dylan Mooijman, Ultan McDermott, the PERSIST-SEQ Consortium   +14 more
doaj   +1 more source

Mitochondrial oxidative phosphorylation (mtOXPHOS) serves as a sentinel to gauge fluctuations under heat stress in Arabidopsis thaliana elucidated by comparative transcriptomics

Plant Stress
Heat stress has destructive effects on crop production and quality posing a grave threat to food security worldwide. Recent studies have elucidated the complicated transcriptional regulatory networks involved in heat stress, but how the organelles of ...
Muhammad Riaz, Erum Yasmeen, Moyang Liu, Hafiz Saqib Ali, Mengli Lv, Hu Shi, Chuanhui Du, Tiantian Dong, Zhenxin Liu, Qingwei Song, QiJun Ma, Kaijing Zuo   +11 more
doaj   +1 more source

Longitudinal Multi-omics and Microbiome Meta-analysis Identify an Asymptomatic Gingival State That Links Gingivitis, Periodontitis, and Aging

mBio, 2021
A significant portion of world population still fails to brush teeth daily. As a result, the majority of the global adult population is afflicted with chronic gingivitis, and if it is left untreated, some of them will eventually suffer from periodontitis.
Shi Huang, Tao He, Feng Yue, Xiujun Xu, Lijiang Wang, Pengfei Zhu, Fei Teng, Zheng Sun, Xiaohui Liu, Gongchao Jing, Xiaoquan Su, Lijian Jin, Jiquan Liu, Jian Xu   +13 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Artificial intelligence‐assisted automatic and index‐based microbial single‐cell sorting system for One‐Cell‐One‐Tube

mLife, 2022
Identification, sorting, and sequencing of individual cells directly from in situ samples have great potential for in‐depth analysis of the structure and function of microbiomes.
Zhidian Diao, Lingyan Kan, Yilong Zhao, Huaibo Yang, Jingyun Song, Chen Wang, Yang Liu, Fengli Zhang, Teng Xu, Rongze Chen, Yuetong Ji, Xixian Wang, Xiaoyan Jing, Jian Xu, Yuandong Li, Bo Ma   +15 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Muscle wasting, resulting from aging or pathological conditions, leads to reduced quality of life, increased morbidity, and increased mortality.
Hyebeen Kim, Sung Chun Cho, Hyeon‐Ju Jeong, Hye‐Young Lee, Myong‐Ho Jeong, Jung‐Hoon Pyun, Dongryeol Ryu, MinSeok Kim, Young‐Sam Lee, Minseok S. Kim, Sang Chul Park, Yun‐Il Lee, Jong‐Sun Kang   +12 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source