Results 71 to 80 of about 734,534 (263)

Leveraging genome wide association studies and single cell RNA sequencing in inflammatory bowel disease

, 2023
In this thesis, the main scientific pursuit is that of leveraging information from genome-wide association studies (GWAS) in combination with gene expression datasets such as to narrow down the list of genes and cell-types that may be important for ...
Voda, Alexandru
core   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine
Cancer immunotherapy is an innovative treatment approach that leverages the immune system to combat tumors, demonstrating significant therapeutic potential.
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Additional file 1 of SMaSH: a scalable, general marker gene identification framework for single-cell RNA-sequencing

, 2022
Additional file 1. Supplementary Material for SMaSH: A scalable, general marker gene identification framework for single-cell RNA ...
S. G. Riva (13218442), M. E. Nelson (13218439), A. Cvejic (13218445)   +2 more
core   +1 more source

Small RNA transcriptome analysis using parallel single-cell small RNA sequencing

Scientific Reports, 2023
miRNA and other forms of small RNAs are known to regulate many biological processes. Single-cell small RNA sequencing can be used to profile small RNAs of individual cells; however, limitations of efficiency and scale prevent its widespread application ...
Jia Li, Zhirong Zhang, Yinghua Zhuang, Fengchao Wang, Tao Cai   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Single-cell RNA sequencing of metastatic testicular seminoma reveals the cellular and molecular characteristics of metastatic cell lineage

, 2022
The Single-cell RNA sequencing data of metastatic testicular seminoma, including tumor tissues, pelvic lymph node (LN1) and renal hilus lymph ...
Zhenyuan Yu (6698111)
core   +1 more source

Splatter: simulation of single-cell RNA sequencing data

Genome Biology, 2017
As single-cell RNA sequencing (scRNA-seq) technologies have rapidly developed, so have analysis methods. Many methods have been tested, developed, and validated using simulated datasets.
Luke Zappia, Belinda Phipson, Alicia Oshlack   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Single-cell ATAC sequencing analysis: From data preprocessing to hypothesis generation

Computational and Structural Biotechnology Journal, 2020
Most genetic variations associated with human complex traits are located in non-coding genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a comprehensive catalog of functional non-coding genomic elements, most of which are ...
Seungbyn Baek, Insuk Lee
doaj   +1 more source