Results 11 to 20 of about 3,861,359 (307)
Clinical Chemistry, 2019 AbstractBACKGROUNDSingle-cell genomics is an approach to investigate cell heterogeneity and to identify new molecular features correlated with clinical outcomes. This approach allows identification of the complexity of cell diversity in a sample without the loss of information that occurs when multicellular or bulk tissue samples are analyzed ...
Paolillo C., Londin E., Fortina P.
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Single-Cell Multiomics: Multiple Measurements from Single Cells [PDF]
Trends in Genetics, 2017 Single-cell sequencing provides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples. Sequencing of one molecular type (RNA, methylated DNA or open chromatin) in a single cell, furthermore, provides insights into the cell's phenotype and links to its genotype.
Macaulay, Iain C. +2 more
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Annual Review of Biomedical Data Science, 2023 Single-cell RNA sequencing methods have led to improved understanding of the heterogeneity and transcriptomic states present in complex biological systems. Recently, the development of novel single-cell technologies for assaying additional modalities, specifically genomic, epigenomic, proteomic, and spatial data, allows for unprecedented insight into ...
Flynn, Emily +2 more
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Clinical and Translational Medicine, 2022 Background The number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear.
Yang‐Yang Wang +10 more
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A stochastic model dissects cell states in biological transition processes [PDF]
, 2013 Many biological processes, including differentiation, reprogramming, and disease transformations, involve transitions of cells through distinct states.
Armond, Jonathan W. +6 more
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Annual Review of Biophysics, 2015 Single-cell techniques have a long history of unveiling fundamental paradigms in biology. Recent improvements in the throughput, resolution, and availability of microfluidics, computational power, and genetically encoded fluorescence have led to a modern renaissance in microbial physiology.
Taheri-Araghi, Sattar +4 more
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Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
Nature Communications, 2023 Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro +5 more
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Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea [PDF]
, 2016 Cell sorting coupled with single-cell genomics is a powerful tool to circumvent cultivation of microorganisms and reveal microbial ‘dark matter’. Single-cell Raman spectra (SCRSs) are label-free biochemical ‘fingerprints’ of individual cells, which can ...
Davison, Paul A. +11 more
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Cells, 2020 Cells are known to be the most fundamental building block of life [...]
Tuhin Subhra Santra, Fan-Gang Tseng
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eLife, 2022 Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz +5 more
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