Results 221 to 230 of about 3,551,300 (318)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Single-cell landscape of piglet lung response with <i>Actinobacillus pleuropneumoniae</i>. [PDF]

Virulence
Zhu J, Zhu S, Xia C, Jiang X, Bao C, Li Z, Zhu R, Jiang H, Li F, Zhang X, Wang W, Chen H, Mei J, Gu J, Li N, Lei L.   +15 more
europepmc   +1 more source

Single-cell identification with quantum-enhanced nuclear magnetic resonance

Zhao, Zhiyuan, Shi, Qian, Xu, Shaoyi, Ye, Xiangyu, Shen, Mengze, Su, Jia, Wang, Ya, Xie, Tianyu, Hu, Qingsong, Shi, Fazhan, Du, Jiangfeng   +10 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genomic evolution of pancreatic cancer at single-cell resolution. [PDF]

Nat Genet
Zhang H, Sashittal P, Karnoub ER, Jakatdar A, Umeda S, Hong J, Noronha AM, Cardenas A, Erakky A, McIntyre CA, Hayashi A, Lecomte N, Hilmi M, Park W, Pang N, O'Reilly EM, Wei AC, Raphael BJ, Iacobuzio-Donahue CA.   +18 more
europepmc   +1 more source

Dynamic LiquidIntegrated Single-Cell SERS PlatformBased on the Twisted Mixing Microfluidic Chip and Multi-Modified Nanoprobefor the Label-Free Detection of Cancer Cells

Jiaqi Yang (4380466), Ziyun Ye (21002301), Qilu Xue (6841709), Dandan Li (391591), Minghui Liang (803052), Guoqian Li (8132625), Huanhuan Liu (169314), Langlang Yi (18334463), Bo Hu (126105), Pengju Yin (18892950), Guanqun Ge (326653), Klyuyev Dmitriy (21002304), Alexandre Maciuk (1969654), Bruno Figadere (21002307)   +13 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A collection of datasets from Publication: Organization of the human intestine at single-cell resolution

John Hickey, Chiara Caraccio, Garry Nolan   +2 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source