Results 1 to 10 of about 4,724,822 (306)

Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis [PDF]

, 2023
Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms.
Nguyen, Tra
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Single-Cell Culture in Microwells

, 2012
In order to better understand cellular processes and behavior, a controlled way of studying high numbers of single cells and their clone formation is greatly needed. This chapter describes a microwell plate with 672 wells in a standard array/slide format,
Lindström, S., Helene Andersson-Svahn, Sara Lindström, Andersson-Svahn, Helene,   +3 more
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Quantitative investigation of calcimimetic R568 on beta cell adhesion and mechanics using AFM single-cell force spectroscopy [PDF]

, 2014
In this study we use a novel approach to quantitatively investigate mechanical and interfacial properties of clonal β-cells using AFM-Single Cell Force Spectroscopy (SCFS). MIN6 cells were incubated for 48hrs with 0.5mM Ca2+ ± the calcimimetic R568 (1μM).
Younis, Mustafa Y.G., Hills, Claire E., Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, Siamantouras, Eleftherios   +5 more
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Single-cell electrical characterization

, 2021
This chapter provides an introduction to single-cell electrical characterization techniques and related devices, which play a key role in the framework of label-free biosensing for diagnostics, drug development, and life science.
Cottet, Jonathan, Federica Caselli, Jonathan Cottet, Caselli, Federica   +3 more
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Single-cell states in the estrogen response of breast cancer cell lines [PDF]

, 2014
Estrogen responsive breast cancer cell lines have been extensively studied to characterize transcriptional patterns in hormone-responsive tumors. Nevertheless, due to current technological limitations, genome-wide studies have typically been limited to ...
Andrea Gamba, Nassa, Giovanni, Roberto Amendola, Mario Nicodemi (81682), Sach Mukherjee (19432), Chris J Oates, Francesco Paolo Casale (526999), Nicodemi, M, Weisz, Alessandro, Gamba, A, Jonathan, W., Alessandro Weisz (90872), Alessandro Weisz, Giorgio Giurato (527000), Giorgio Giurato, Gamba, Andrea, Cora', Davide, Chris J. Oates, Gamba, Andrea Antonio, Armond, Jonathan W., Weisz, A, Amendola, Roberto, Mukherjee, Sach, Casale, Francesco Paolo, Oates, Chris J., Jonathan W. Armond, Mario Nicodemi, Oates, CJ, Giovanni Nassa, Davide Corá, Nassa, G, Corá, Davide, Ro Weisz, Mukherjee, S, Giovanni Nassa (527001), Chris J. Oates (527003), Francesco Paolo Casale, Giurato, Giorgio, Andrea Gamba (181217), Nicodemi, Mario, Sach Mukherjee, Davide Cor?, Giurato, G, Corá, D, Chris, J., Jonathan W Armond, Davide Corá (5649682), Armond, JW, Jonathan W. Armond (527002), Casale, FP   +49 more
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Single-cell specificity analysis.

, 2022
A. The Jaccard-Index is used to compare the imputed profiles from SIMPA with the origin human bulk profile used to create a simulated sparse profile and the consensus profile representing the remaining experiments available for the same biosample-target ...
Miguel A. Andrade-Navarro (31443), Jean Fred Fontaine (12988237), Steffen Albrecht (483443), Tommaso Andreani (7880516)   +3 more
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Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules [PDF]

, 2023
Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods.
Lan, Yunpeng
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DEVELOPMENT AND APPLICATION OF SINGLE CELL MASS SPECTROMETRY TECHNIQUES FOR NON-ADHERENT CELL ANALYSIS [PDF]

, 2020
Mass spectrometry (MS) analysis of biological samples is traditionally carried out using extractions from large populations of cells, concealing the information from individual cells.
Zhu, Yanlin
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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells [PDF]

, 2021
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B
Greiff, Victor,, Borcherding, Nicholas, Bernasconi, Valentina, Lebrero-Fern\ue1ndez, Cristina, Smirnov, Ilya, Lebrero-Fernández, Cristina,, Mathew, Nimitha R.,, Schön, Karin,, Nakka, Sravya S.,, Jayanthan, Jayalal K., Yewdell, Jonathan W.,, Lebrero-Fernández, Cristina, Axelsson, Hannes, Yewdell, Jonathan W., Robinson, Jonathan, Rodin, William, Czarnewski, Paulo, Greiff, Victor, Angeletti, Davide,, Harandi, Ali M., Kalathilparambil Jayanthan, Jayalal, Rodin, William,, Robinson, Jonathan,, Bernasconi, V.,, Borcherding, Nicholas,, Axelsson, Hannes,, Lycke, Nils, Robinson, Jonathan L., Czarnewski, Paulo,, Angeletti, Davide, Sch\uf6n, Karin, Bernasconi, V., Smirnov, Ilya V., Smirnov, Ilya V.,, Lycke, N. Y.,, Yewdell, William T.,, Bemark, Mats, Nakka, Sravya S., Schön, Karin, Lycke, Nils Y., Yewdell, William T., Emmanouilidi, Aikaterini, Lycke, N. Y., Mathew, Nimitha R., Harandi, A. M., Bemark, Mats,, Harandi, A. M.,, Emmanouilidi, Aikaterini,, Jayanthan, Jayalal K.,   +48 more
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Stephenson Covid-19 PBMC 2021 TCR

, 2023
Dataset published by Stephenson et al. 2021, which contains transcriptome sequencing for over 750,000 Peripheral Blood Mononuclear Cells (PBMC) from 130 patients in the context of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) The dataset ...
Single-cell best practices (14656733)
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