Results 21 to 30 of about 5,699,590 (286)
Hierarchical mechanism of amino acid sensing by the T-box riboswitch
Nature Communications, 2018 Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution ...
Krishna C. Suddala +5 more
doaj +1 more source
Microfluidics-Based Single-Cell Research for Intercellular Interaction
Frontiers in Cell and Developmental Biology, 2021 Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and medical studies, such as stem cell differentiation, immunotherapy and tissue engineering. Traditional methods employed for delving into intercellular interaction
Long Pang +10 more
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Microfluidic Single-Cell Manipulation and Analysis: Methods and Applications
Micromachines, 2019 In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a genetically identical group are the same. This heterogeneity at the single-cell level has been recognized to be vital for the correct interpretation of ...
Tao Luo, Lei Fan, Rong Zhu, Dong Sun
doaj +1 more source
scDA: Single cell discriminant analysis for single-cell RNA sequencing data
Computational and Structural Biotechnology Journal, 2021 Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi +4 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2004 Resistance and susceptibility in barley to the powdery mildew fungus (Blumeria graminis f. sp. hordei) is determined at the single-cell level. Even in genetically compatible interactions, attacked plant epidermal cells defend themselves against attempted
Torben Gjetting +3 more
doaj +1 more source
Automated single-cell motility analysis on a chip using lensfree microscopy. [PDF]
, 2014 Quantitative cell motility studies are necessary for understanding biophysical processes, developing models for cell locomotion and for drug discovery.
Di Carlo, Dino +6 more
core +1 more source
SCALA: A complete solution for multimodal analysis of single-cell Next Generation Sequencing data
Computational and Structural Biotechnology Journal, 2023 Analysis and interpretation of high-throughput transcriptional and chromatin accessibility data at single-cell (sc) resolution are still open challenges in the biomedical field.
Christos Tzaferis +5 more
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DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. [PDF]
, 2018 An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity.
Anchang, Benedict +8 more
core +1 more source
Development of Droplet Microfluidics Enabling High-Throughput Single-Cell Analysis
Molecules, 2016 This article reviews recent developments in droplet microfluidics enabling high-throughput single-cell analysis. Five key aspects in this field are included in this review: (1) prototype demonstration of single-cell encapsulation in microfluidic droplets;
Na Wen +6 more
doaj +1 more source
Single Cell Analysis in Vascular Biology
Frontiers in Cardiovascular Medicine, 2020 The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within tissues.
Nicholas W. Chavkin +2 more
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