Results 21 to 30 of about 32,538,527 (305)
Single-cell protein analysis [PDF]
Current Opinion in Biotechnology, 2012 Heterogeneity of cellular systems has been widely recognized but only recently have tools become available that allow probing of genes and proteins in single cells to understand it. While the advancement in single cell genomic analysis has been greatly aided by the power of amplification techniques (e.g.
Meiye, Wu, Anup K, Singh
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Microfluidics-Based Single-Cell Research for Intercellular Interaction
Frontiers in Cell and Developmental Biology, 2021 Intercellular interaction between cell–cell and cell–ECM is critical to numerous biology and medical studies, such as stem cell differentiation, immunotherapy and tissue engineering. Traditional methods employed for delving into intercellular interaction
Long Pang +10 more
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Transcriptome Analysis of Single Cells [PDF]
Journal of Visualized Experiments, 2011 Many gene expression analysis techniques rely on material isolated from heterogeneous populations of cells from tissue homogenates or cells in culture. In the case of the brain, regions such as the hippocampus contain a complex arrangement of different cell types, each with distinct mRNA profiles.
Morris, Jacqueline +2 more
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Single Cell Mass Spectrometry Metabolomics Study of Drug-resistant Cells [PDF]
, 2022 Single cell analysis is an emerging area to reveal the heterogeneity of individual cells among all populations. Understanding the cell-to-cell variation can greatly promote the development of drug discovery, disease diagnostics and prognostics ...
Chen, Xingxiu
core
Microfluidic Single-Cell Manipulation and Analysis: Methods and Applications
Micromachines, 2019 In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a genetically identical group are the same. This heterogeneity at the single-cell level has been recognized to be vital for the correct interpretation of ...
Tao Luo, Lei Fan, Rong Zhu, Dong Sun
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scDA: Single cell discriminant analysis for single-cell RNA sequencing data
Computational and Structural Biotechnology Journal, 2021 Single-cell RNA-sequencing (scRNA-seq) techniques provide unprecedented opportunities to investigate phenotypic and molecular heterogeneity in complex biological systems.
Qianqian Shi +4 more
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Molecular Plant-Microbe Interactions, 2004 Resistance and susceptibility in barley to the powdery mildew fungus (Blumeria graminis f. sp. hordei) is determined at the single-cell level. Even in genetically compatible interactions, attacked plant epidermal cells defend themselves against attempted
Torben Gjetting +3 more
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Single Cell Analysis in Vascular Biology
Frontiers in Cardiovascular Medicine, 2020 The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within tissues.
Nicholas W. Chavkin +2 more
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SCALA: A complete solution for multimodal analysis of single-cell Next Generation Sequencing data
Computational and Structural Biotechnology Journal, 2023 Analysis and interpretation of high-throughput transcriptional and chromatin accessibility data at single-cell (sc) resolution are still open challenges in the biomedical field.
Christos Tzaferis +5 more
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Development of Droplet Microfluidics Enabling High-Throughput Single-Cell Analysis
Molecules, 2016 This article reviews recent developments in droplet microfluidics enabling high-throughput single-cell analysis. Five key aspects in this field are included in this review: (1) prototype demonstration of single-cell encapsulation in microfluidic droplets;
Na Wen +6 more
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