Results 1 to 10 of about 13,531,309 (317)

Organoid technology in cancer research

Molecular Biomedicine
Organoid technology has emerged as a transformative tool in cancer research by recapitulating the structural complexity, genomic integrity, and phenotypic heterogeneity of human primary tumors.
Jingjing Zhang, Jian He
doaj   +1 more source

Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana

Plants
Mitochondria are important organelles in eukaryotes and are involved in various metabolic processes. Mitochondrial proteotoxic stress triggers the mitochondrial unfolded protein response (UPRmt) to restore mitochondrial protein homeostasis and maintain ...
Guolong Yu, Zhuoran Huang, Chaocheng Guo, Jiahao Li, Xinyuan Wang, Yudong Wang, Xu Wang   +6 more
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Mapping NK cell diversity in response to COVID-19 and mRNA vaccination

Scientific Reports
Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood.
Yosuke Kishi, Yu-Chen Liu, Masakazu Ishikawa, Maika Yamashita, Hisatake Matsumoto, Hiroshi Ogura, Shuhei Sakakibara, Daisuke Okuzaki   +7 more
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The hidden mycobiome: emerging role in anticancer immunotherapy

Mycology
As one of the emerging hallmarks, the mycobiome has recently gained significant recognition in cancer research, especially regarding anticancer immunotherapy.
Ze-Chang Peng, Xin-Yu Liu, Qin-Yu Liu, Wan-Qing Lu, Chen-Ze Jin, Tian-Yi Zhang, Ning-Ning Liu   +6 more
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Molecular regulatory networks of microplastics and cadmium mediated hepatotoxicity from NAFLD to tumorigenesis via integrated approaches

Ecotoxicology and Environmental Safety
Microplastics (MPs), as emerging environmental pollutants, not only possess inherent toxicity but also adsorb or carry other hazardous substances, such as the carcinogen cadmium (Cd), leading to more complex public health issues.
Yuhan Li, Yulun Jian, Jinjin Zhou, Min Zhang, Yanfeng Zhou, Yang Ge, Hui Wang, Wei Mu   +7 more
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DNA methylation dynamics in male germline development in Brassica Rapa

Molecular Horticulture
Dynamic DNA methylation represses transposable elements (TEs) and regulates gene activity, playing a pivotal role in plant development. Although substantial progress has been made in understanding DNA methylation reprogramming during germline development
Jun Zhang, Di Wu, Yating Zhang, Xiaoqi Feng, Hongbo Gao   +4 more
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High-throughput Raman-activated cell sorting of microalgal genome-wide edited library revealed a regulatory pathway for carotenoid synthesis

Nature Communications
Functional genomics have been hampered by the paucity of efficient methods that connect genotype and metabolic phenotype at single-cell resolution.
Qintao Wang, Yanhai Gong, Lianhong Wang, Nana Lv, Xuefeng Du, Jiashun Zhang, Yi Xin, Zoran Nikoloski, Yonghua Li-Beisson, Luyang Sun, Bo Ma, Xixian Wang, Jian Xu   +12 more
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Identification of Novel Regulators of Leaf Senescence Using a Deep Learning Model

Plants
Deep learning has emerged as a powerful tool for investigating intricate biological processes in plants by harnessing the potential of large-scale data. Gene regulation is a complex process that transcription factors (TFs), cooperating with their target ...
Chaocheng Guo, Zhuoran Huang, Jiahao Chen, Guolong Yu, Yudong Wang, Xu Wang   +5 more
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Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain

Cell Reports
Summary: Caloric restriction (CR) is a well-studied intervention that extends lifespan and slows cognitive decline across species, yet the specific cell populations and molecular pathways involved remain elusive. In this study, we profiled >500,000 cells
Zehao Zhang, Alexander Epstein, Chloe Schaefer, Abdulraouf Abdulraouf, Weirong Jiang, Wei Zhou, Junyue Cao   +6 more
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Building digital pregnancies from the single cell up. [PDF]

Sci Adv
Scott AK.
europepmc   +1 more source