Results 1 to 10 of about 3,900,612 (318)
Clinical Chemistry, 2019 AbstractBACKGROUNDSingle-cell genomics is an approach to investigate cell heterogeneity and to identify new molecular features correlated with clinical outcomes. This approach allows identification of the complexity of cell diversity in a sample without the loss of information that occurs when multicellular or bulk tissue samples are analyzed ...
Paolillo C., Londin E., Fortina P.
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Antifungal Nanomaterials: Current Progress and Future Directions [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 Fungal infection poses a severe threat to human health worldwide resulting in a serious problem in clinic. Due to the limited arsenal of existing antifungal drugs, the nanomaterials were thus regarded as the candidate for developing new antifungal drugs.
Jia-Le Xu +4 more
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, 2021 Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a ...
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Biotechnology for Biofuels, 2021 Background Triacylglycerol (TAG) is an important storage lipid in organisms, depending on the degree of unsaturation of fatty acid molecules attached to glycerol; it is usually used as the feedstock for nutrition or biodiesel.
Chuanzeng Lan +8 more
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Single-Cell Multiomics: Multiple Measurements from Single Cells [PDF]
Trends in Genetics, 2017 Single-cell sequencing provides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples. Sequencing of one molecular type (RNA, methylated DNA or open chromatin) in a single cell, furthermore, provides insights into the cell's phenotype and links to its genotype.
Macaulay, Iain C. +2 more
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Single molecule and single cell epigenomics [PDF]
Methods, 2015 Dynamically regulated changes in chromatin states are vital for normal development and can produce disease when they go awry. Accordingly, much effort has been devoted to characterizing these states under normal and pathological conditions. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most widely used method to characterize ...
Byung-Ryool, Hyun +2 more
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Biotechnology for Biofuels, 2020 Background Phosphopantetheinyl transferase (PPTase) can change the acyl-carrier protein (ACP) from an inactive apo-ACP to an active holo-ACP that plays a key role in fatty acids biosynthesis.
Sen Wang +5 more
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Application of single-cell multi-omics approaches in horticulture research
Molecular Horticulture, 2023 Cell heterogeneity shapes the morphology and function of various tissues and organs in multicellular organisms. Elucidation of the differences among cells and the mechanism of intercellular regulation is essential for an in-depth understanding of the ...
Jun Zhang, Mayra Ahmad, Hongbo Gao
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Frontiers in Nutrition, 2021 Black chokeberry or aronia (the fruit of Aronia melanocarpa) has been reported to having pharmacological activities against metabolic syndrome, such as hypertension, obesity, diabetes, and pro-inflammatory conditions.
Chae-Eun Yun +14 more
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Single-cell profiling of transcriptome and histone modifications with EpiDamID [PDF]
, 2022 Recent advances in single-cell sequencing technologies have enabled simultaneous measurement of multiple cellular modalities, but the combined detection of histone post-translational modifications and transcription at single-cell resolution has remained ...
Rang, Franka J +14 more
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