Results 21 to 30 of about 12,921,630 (316)

Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

Nature Communications, 2023
Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro, David M. Rutkowski, Kelli Ann Lynch, Ying Liu, Dimitrios Vavylonis, Naoki Watanabe   +5 more
doaj   +1 more source

Rehabilitation and the single cell [PDF]

Current Opinion in Cell Biology, 2007
Cellular damage triggers rapid resealing of the plasma membrane and repair of the cortical cytoskeleton. Plasma membrane resealing results from calcium-dependent fusion of membranous organelles and the plasma membrane at the site of the damage.
William M, Bement, Hoi-Ying E, Yu, Brian M, Burkel, Emily M, Vaughan, Andrew G, Clark   +4 more
openaire   +2 more sources

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

eLife, 2022
Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz, Aaron R Hall, Eiji Usukura, Sawako Yamashiro, Naoki Watanabe, Dimitrios Vavylonis   +5 more
doaj   +1 more source

Single-Cell Physiology [PDF]

Annual Review of Biophysics, 2015
Single-cell techniques have a long history of unveiling fundamental paradigms in biology. Recent improvements in the throughput, resolution, and availability of microfluidics, computational power, and genetically encoded fluorescence have led to a modern renaissance in microbial physiology.
Taheri-Araghi, Sattar, Brown, Steven D, Sauls, John T, McIntosh, Dustin B, Jun, Suckjoon   +4 more
openaire   +4 more sources

Quantitative investigation of calcimimetic R568 on beta cell adhesion and mechanics using AFM single-cell force spectroscopy [PDF]

, 2014
In this study we use a novel approach to quantitatively investigate mechanical and interfacial properties of clonal β-cells using AFM-Single Cell Force Spectroscopy (SCFS). MIN6 cells were incubated for 48hrs with 0.5mM Ca2+ ± the calcimimetic R568 (1μM).
Younis, Mustafa Y.G., Hills, Claire E., Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, Siamantouras, Eleftherios   +5 more
core   +1 more source

The inhibition of chloride intracellular channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells

Experimental and Molecular Medicine, 2019
Cancer: chloride transport protein protects tumors A chloride channel, a membrane protein involved in chloride transport, indirectly regulates calcium signaling to protect cancer cells from free radicals and DNA damage.
Jae-Rin Lee, Jong-Yoon Lee, Hyun-Ji Kim, Myong-Joon Hahn, Jong-Sun Kang, Hana Cho   +5 more
doaj   +1 more source

Genome-wide identification of nitrate transporter genes from Spirodela polyrhiza and characterization of SpNRT1.1 function in plant development

Frontiers in Plant Science, 2022
Nitrate transporter (NRT) genes that participate in nitrate transport and distribution are indispensable for plant growth, development, and stress tolerance.
Mengli Lv, Tiantian Dong, Jin Wang, Kaijing Zuo   +3 more
doaj   +1 more source

Single-cell states in the estrogen response of breast cancer cell lines [PDF]

, 2014
Estrogen responsive breast cancer cell lines have been extensively studied to characterize transcriptional patterns in hormone-responsive tumors. Nevertheless, due to current technological limitations, genome-wide studies have typically been limited to ...
Andrea Gamba, Nassa, Giovanni, Roberto Amendola, Mario Nicodemi (81682), Sach Mukherjee (19432), Chris J Oates, Francesco Paolo Casale (526999), Nicodemi, M, Weisz, Alessandro, Gamba, A, Jonathan, W., Alessandro Weisz (90872), Alessandro Weisz, Giorgio Giurato (527000), Giorgio Giurato, Gamba, Andrea, Cora', Davide, Chris J. Oates, Gamba, Andrea Antonio, Armond, Jonathan W., Weisz, A, Amendola, Roberto, Mukherjee, Sach, Casale, Francesco Paolo, Oates, Chris J., Jonathan W. Armond, Mario Nicodemi, Oates, CJ, Giovanni Nassa, Davide Corá, Nassa, G, Corá, Davide, Ro Weisz, Mukherjee, S, Giovanni Nassa (527001), Chris J. Oates (527003), Francesco Paolo Casale, Giurato, Giorgio, Andrea Gamba (181217), Nicodemi, Mario, Sach Mukherjee, Davide Cor?, Giurato, G, Corá, D, Chris, J., Jonathan W Armond, Davide Corá (5649682), Armond, JW, Jonathan W. Armond (527002), Casale, FP   +49 more
core   +1 more source

IGDB-DuLab/Single-cell-phenotype-analysis: SCPA_code

, 2022
This repository contains the source code used in our study titled "Defect-Buffering Cellular Plasticity Increases Robustness of Metazoan Embryogenesis". The provided scripts allow quantification and phenotypic determination of six types of developmental ...
IGDB-DuLab
core   +1 more source

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus [PDF]

, 2022
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistance ...
Ko, Dennis C., Bergstrom, Emma, Brennan, Richard G, Brennan, Richard G., Jack Anderson, Christopher W. Woods, Erica J. Washington, Chiu, Christopher, Harding, Alfred T., Micah T. McClain, McClain, Micah T., Alfred T. Harding, Schott, Benjamin H, Ko, Dennis C, Gregory, Simon G., Zhu, Xinyu, Bourgeois, Jeffrey S, Gregory, Simon G, McClain, Micah T, Emily R. Ko, Heaton, Nicholas S., Dennis C. Ko, Richard G. Brennan, Zoe Gardener, Paterson, Suzanna, Nicholas S. Heaton, Wang, Liuyang, Washington, Erica J., Woods, Christopher W., Liuyang Wang, Heaton, Nicholas S, Benjamin H. Schott, Schott, Benjamin H., Woods, Christopher W, Thomas W. Burke, Anderson, Jack, Christopher Chiu, Bourgeois, Jeffrey S., Suzanna Paterson, Ko, Emily R, Washington, Erika J, Emma Bergstrom, Xinyu Zhu, Harding, Alfred T, Burke, Thomas W., Jeffrey S. Bourgeois, Gardener, Zoe, Ko, Emily R., Burke, Thomas W, Simon G. Gregory   +49 more
core   +1 more source