Results 41 to 50 of about 12,921,630 (316)

Single cell metabolomics [PDF]

Current Opinion in Biotechnology, 2011
Recent discoveries suggest that cells of a clonal population often display multiple metabolic phenotypes at the same time. Motivated by the success of mass spectrometry (MS) in the investigation of population-level metabolomics, the analytical community has initiated efforts towards MS-based single cell metabolomics to investigate metabolic phenomena ...
Heinemann M, Zenobi R
openaire   +3 more sources

Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules [PDF]

, 2023
Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods.
Lan, Yunpeng
core  

Single Cell Mass Spectrometry Metabolomics Study of Drug-resistant Cells [PDF]

, 2022
Single cell analysis is an emerging area to reveal the heterogeneity of individual cells among all populations. Understanding the cell-to-cell variation can greatly promote the development of drug discovery, disease diagnostics and prognostics ...
Chen, Xingxiu
core  

scGSECA:identification of altered biological processes in single-cell RNA-sequencing data by discretization of expression profiles

, 2023
Bimodality of the distribution of expression levels has been observed in bulk RNA-seq. Two possible explanations underpin this kind of partitioning and refer to opposite paradigmatic models.
Salvatore Oliviero, Michele Caselle, Matteo Cereda, Andrea Lauria, Serena Peirone, Francesca Priante, Sarah Perrone   +6 more
core   +2 more sources

Longitudinal Multi-omics and Microbiome Meta-analysis Identify an Asymptomatic Gingival State That Links Gingivitis, Periodontitis, and Aging

mBio, 2021
A significant portion of world population still fails to brush teeth daily. As a result, the majority of the global adult population is afflicted with chronic gingivitis, and if it is left untreated, some of them will eventually suffer from periodontitis.
Shi Huang, Tao He, Feng Yue, Xiujun Xu, Lijiang Wang, Pengfei Zhu, Fei Teng, Zheng Sun, Xiaohui Liu, Gongchao Jing, Xiaoquan Su, Lijian Jin, Jiquan Liu, Jian Xu   +13 more
doaj   +1 more source

Single Cell Electrical Characterization Techniques

, 2016
International audienceIn this chapter the possibility to electrically characterize the electroporation of single cells is discussed. During the electroporation process, the application of pulsed electric field (Transmembrane Voltage Induced by Applied ...
Olivier Français, Français, Olivier, Le Pioufle, Bruno, Bruno Le Pioufle   +3 more
core   +1 more source

Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features

Nature Communications
Cancer arises from genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To chart cancer-intrinsic regulatory programs, we build a pan-cancer single-cell atlas of 60 cancer cell lines spanning ...
Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao   +8 more
doaj   +1 more source

Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity

Journal for ImmunoTherapy of Cancer, 2023
Background Antineoplastic chemotherapies are dramatically efficient when they provoke immunogenic cell death (ICD), thus inducing an antitumor immune response and even tumor elimination.
Hui Wang, Mayu Sun, Xiaoguang Li, Jingquan Li, Jingyang Li, Huiyi Chen, Xiaoyu Han, Weida Li, Guanghuan Yang, Bao Guo   +9 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models

Genome Biology
The 10 × Genomics Flex Gene Expression protocol is a probe-based method that profiles fixed or frozen material, simplifying sample handling before scRNA-seq.
Oriol Llorà-Batlle, Anca Farcas, Doreth Fransen, Nicolas Floc’h, Sara Talbot, Alix Schwiening, Laura Bojko, John Calver, Natasa Josipovic, Kanstantsin Lashuk, Julia Schueler, Andrei Prodan, Dylan Mooijman, Ultan McDermott, the PERSIST-SEQ Consortium   +14 more
doaj   +1 more source