Results 51 to 60 of about 13,531,309 (317)

Single cell metabolomics [PDF]

Current Opinion in Biotechnology, 2011
Recent discoveries suggest that cells of a clonal population often display multiple metabolic phenotypes at the same time. Motivated by the success of mass spectrometry (MS) in the investigation of population-level metabolomics, the analytical community has initiated efforts towards MS-based single cell metabolomics to investigate metabolic phenomena ...
Heinemann M, Zenobi R
openaire   +3 more sources

Single-Cell Culture in Microwells

, 2012
In order to better understand cellular processes and behavior, a controlled way of studying high numbers of single cells and their clone formation is greatly needed. This chapter describes a microwell plate with 672 wells in a standard array/slide format,
Lindström, S., Helene Andersson-Svahn, Sara Lindström, Andersson-Svahn, Helene,, Lindström, S, Andersson-Svahn, H   +5 more
core   +1 more source

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

, 2023
Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Parashar Dhapola, Säwén, Petter, Karlsson, Göran, Anna Konturek-Ciesla, David Bryder, Wan, Haixia, Göran Karlsson, Bryder, David, Haixia Wan, Qinyu Zhang, Petter Säwén, Zhang, Qinyu, Konturek-Ciesla, Anna, Dhapola, Parashar, Dhapola, Parashar,, Karlsson, Göran,, Bryder, David,, Wan, Haixia,, Zhang, Qinyu,, Säwén, Petter,, Konturek-Ciesla, Anna,, Lund University.   +21 more
core   +1 more source

agitter/single-cell-pseudotime: 2018-06-25 archive

, 2018
<p>An overview of algorithms for estimating pseudotime in single-cell RNA-seq data.  Initial archive for Zenodo DOI and citation. Adopting release practices from <a href="https://github.com/seandavi/awesome-single-cell">https ...
Anthony Gitter, Anthony Gitter (142451)
core   +1 more source

xilin93/Single-cell-analysis-of-GF-SI-CD4-cells: GFSICD4V1.0.0

, 2023
Full Changelog: https://github.com/xilin93/Single-cell-analysis-of-GF-SI-CD4-cells/commits/V1.0.
xilin93
core   +1 more source

Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features

Nature Communications
Cancer arises from genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To chart cancer-intrinsic regulatory programs, we build a pan-cancer single-cell atlas of 60 cancer cell lines spanning ...
Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao   +8 more
doaj   +1 more source

Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity

Journal for ImmunoTherapy of Cancer, 2023
Background Antineoplastic chemotherapies are dramatically efficient when they provoke immunogenic cell death (ICD), thus inducing an antitumor immune response and even tumor elimination.
Hui Wang, Mayu Sun, Xiaoguang Li, Jingquan Li, Jingyang Li, Huiyi Chen, Xiaoyu Han, Weida Li, Guanghuan Yang, Bao Guo   +9 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Single-Cell-Derived Tumor-Sphere Formation and Drug-Resistance Assay Using an Integrated Microfluidics

, 2019
Considerable evidence points to cancer stem-like cells (CSCs) as responsible for promoting progression, metastasis, and drug resistance. Without damage to the cell biological properties, single-cell-derived tumor-sphere is encouraging options for CSCs ...
Jing Ding, Long Pang (457760), Long Pang, Jianglin Fan (448849), Yuxin Ge, Yuxin Ge (5988779), Shih-Kang Fan (733610), Jianglin Fan, Shih-Kang Fan, Jing Ding (32381)   +9 more
core   +1 more source

10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models

Genome Biology
The 10 × Genomics Flex Gene Expression protocol is a probe-based method that profiles fixed or frozen material, simplifying sample handling before scRNA-seq.
Oriol Llorà-Batlle, Anca Farcas, Doreth Fransen, Nicolas Floc’h, Sara Talbot, Alix Schwiening, Laura Bojko, John Calver, Natasa Josipovic, Kanstantsin Lashuk, Julia Schueler, Andrei Prodan, Dylan Mooijman, Ultan McDermott, the PERSIST-SEQ Consortium   +14 more
doaj   +1 more source