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Single‐Cell Microelectrochemistry

Angewandte Chemie International Edition, 2007
AbstractNeedle‐type voltammetric ultramicroelectrodes show exceptional sensitivity for the detection of redox‐active substances, rapid response times, and total tip diameters in the lower micrometer range. These characteristics make them ideal for analyzing the chemical environment and the activity of isolated living cells, which in their various forms
Albert, Schulte, Wolfgang, Schuhmann
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Single-Cell Protein

Biotechnology and Genetic Engineering Reviews, 1984
This chapter describes how an industrial organization has approached the development of a single-cell protein (SCP) process, from the choice of substrate to the commissioning of the world's largest continuous fermentation plant. SCP offers a new challenge to the process engineer of fermentation at enormously increased scale.
R B, Vasey, K A, Powell
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Single-cell biomedicine: roles of single-cell nuclear elements

Cell Biology and Toxicology, 2020
Single-cell biomedicine, a new merging discipline of cell biology and medicine to improve the life quality of patients, gains high priority in cell biology and toxicology. Single-cell nuclear elements are specially focused and headlined to understand regulatory mechanisms by which transcriptional factors, DNA elements, and genome organization interact ...
Yiming Zeng   +2 more
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Single-Cell Metabolomics

2017
The dynamics of a cell is always changing. Cells move, divide, communicate, adapt, and are always reacting to their surroundings non-synchronously. Currently, single-cell metabolomics has become the leading field in understanding the phenotypical variations between them, but sample volumes, low analyte concentrations, and validating gentle sample ...
Samy, Emara   +5 more
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Single-cell electroporation

Analytical and Bioanalytical Chemistry, 2010
Single-cell electroporation (SCEP) is a relatively new technique that has emerged in the last decade or so for single-cell studies. When a large enough electric field is applied to a single cell, transient nano-pores form in the cell membrane allowing molecules to be transported into and out of the cell.
Manyan, Wang   +3 more
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Single cell technology

Current Opinion in Plant Biology, 2003
Complexity is a fundamental feature of life. Like animals, higher plants consist of a multitude of different distinct tissues and cell types, each contributing to the overall performance of the whole organism. Our understanding and knowledge of physiology will greatly increase as our ability to spatially resolve molecular and biochemical processes ...
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Single-Cell Transcriptional Analysis

Annual Review of Analytical Chemistry, 2017
Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that would otherwise be challenging or even impossible.
Wu, Angela Ruohao   +3 more
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Microfluidic Single-Cell Analytics

2020
What is the impact of cellular heterogeneity on process performance? How do individual cells contribute to averaged process productivity? Single-cell analysis is a key technology for answering such key questions of biotechnology, beyond bulky measurements with populations.
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Single-Cell Western Blotting

2015
Cell heterogeneity is a variation in cellular processes in functionally similar cells. Cells from the same tissue which are considered genetically identical may have difference in size, structure, and level of protein expression which can lead to major impact on the functions of cell leading to difference in physiological consequences.
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