Results 81 to 90 of about 3,861,359 (307)

Lineage dynamics of murine pancreatic development at single-cell resolution. [PDF]

, 2018
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time.
Byrnes, Lauren E, Gilchrist, Caroline L, Knox, Sarah M, Meyer, Nathaniel P, Sneddon, Julie B, Subramaniam, Meena, Tward, Aaron D, Wong, Daniel M, Ye, Chun J   +8 more
core   +2 more sources

Single-cell genetics [PDF]

Nature Methods, 2013
Single-cell measurements enable more sophisticated studies of the genetic basis of gene expression phenotypes.
openaire   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Single-cell Raman-activated sorting and cultivation (scRACS-Culture) for assessing and mining in situ phosphate-solubilizing microbes from nature

ISME Communications, 2022
Due to the challenges in detecting in situ activity and cultivating the not-yet-cultured, functional assessment and mining of living microbes from nature has typically followed a ‘culture-first’ paradigm.
Xiaoyan Jing, Yanhai Gong, Huihui Pan, Yu Meng, Yishang Ren, Zhidian Diao, Runzhi Mu, Teng Xu, Jia Zhang, Yuetong Ji, Yuandong Li, Chen Wang, Lingyun Qu, Li Cui, Bo Ma, Jian Xu   +15 more
doaj   +1 more source

Simultaneous profiling of transcriptome and DNA methylome from a single cell. [PDF]

, 2016
BackgroundSingle-cell transcriptome and single-cell methylome technologies have become powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide scale. A major challenge has been to understand the direct correlation of DNA
An, Qin, Du, Guizhen, Fan, Guoping, Hu, Ganlu, Hu, Youjin, Huang, Kevin, Wang, Cun-Yu, Xue, Jinfeng, Xue, Zhigang, Zhu, Xianmin   +9 more
core   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice

Nature Communications, 2021
The impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of ...
Chaobao Liu, Yang Yang, Cheng Chen, Ling Li, Jingquan Li, Xiaonan Wang, Qiao Chu, Lin Qiu, Qian Ba, Xiaoguang Li, Hui Wang   +10 more
doaj   +1 more source

SCALE method for single-cell ATAC-seq analysis via latent feature extraction. [PDF]

, 2019
Single-cell ATAC-seq (scATAC-seq) profiles the chromatin accessibility landscape at single cell level, thus revealing cell-to-cell variability in gene regulation.
Gao, Ge, Jiang, Tao, Shao, Yanqiu, Tang, Lei, Tian, Kang, Xiong, Lei, Xu, Kui, Zhang, Michael, Zhang, Qiangfeng Cliff   +8 more
core  

Stochastic modeling for the COMET-assay [PDF]

, 2003
We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. Essential is the use of point process structures, renewal theory and reduction to intensity histograms for further data ...
Boulesteix, Anne-Laure, Hösel, V., Liebscher, V.   +2 more
core   +3 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source