Results 171 to 180 of about 4,737,492 (306)

Paired single cell analysis reveals chemotherapy resistance in osteosarcoma. [PDF]

Cancer Drug Resist
Hu L, Zhang Y, Wang B, Liu Q, Qi F, Liu H, Li Q, Zhao Z, Liang H, Liu X, Du Z, Wang J.   +11 more
europepmc   +1 more source

Single-Cell and Transcriptome Analysis of Periodontitis: Molecular Subtypes and Biomarkers Linked to Mitochondrial Dysfunction and Immunity

Journal of Inflammation Research
Sijia Ma,1,2 Hongbing He,1,2 Xiaobin Ren1,2 1Department of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming, 650106, People’s Republic of China; 2Yunnan Key Laboratory of Stomatology, Kunming, 650106, People’s ...
Ma S, He H, Ren X
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

ProtoCloud: A prototypical self-explaining model for single-cell analysis. [PDF]

Cell Genom
Guo K, Ding J.
europepmc   +1 more source

Single-Cell Analysis Identifies Distinct Populations of Cytotoxic CD4+ T Cells Linked to the Therapeutic Efficacy of Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

Journal of Inflammation Research
Xu Yang,1,* Jianwei Wu,1,* Longlong Fan,2 Binghua Chen,3 Shiqiang Zhang,4 Wenzhong Zheng1 1Department of Urology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Department of Urology, The Eighth Affiliated Hospital,
Yang X, Wu J, Fan L, Chen B, Zhang S, Zheng W   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Single-cell analysis of HIV envelope-induced signaling.

, 2006
Single-cell analysis of HIV envelope-induced ...
Marta. Melar (7978268)
core  

Single-cell transcriptome analysis of HSCs.

(A). UMAP representation depicting the transcriptional profiles of individual HSCs (LSK CD48- CD150+). (B) S-phase score along pseudotime. (C) G2/M phase score along pseudotime. (D) Dormancy score along pseudotime.
Anupam Sinha (1974100), Andreas Dahl (2696749), Tatyana Grinenko (18078786), Malte von Bonin (400911), Juan Alberto Pérez-Valencia (18078780), Sema Elif Eski (10899813), Manja Wobus (326146), Liliia Ibneeva (18078774), Susanne Reinhardt (7824746), Martin Bornhäuser (219605), Sumeet Pal Singh (10899822), Alexander Gerbaulet (558872), Iryna Kovtun (18078777), Ben Wielockx (13181916), Jaime Sancho (329189), Marc Schmitz (357415), Rebekka Wehner (357414), Frances Lund (18078783), Triantafyllos Chavakis (5816888), Luise Rupp (15167618)   +19 more
core   +1 more source

Multi-organ single-cell analysis of preferential expression of CAKUT genes. [PDF]

BMC Nephrol
Pflugfelder M, Eberts A, Koch V, Martynov I, Maj C, Seitz G, Schumacher J, Vahdad MR, Dasmeh P.   +8 more
europepmc   +1 more source

Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis

Journal of Inflammation Research
Zhuo Zhao,1,* Ziyu Liu,2,* Qun Wang,3,4 Hao Gao,1 Nan Song,5 Xiao Yang1,2 1The Second Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 2The Second Affiliated
Zhao Z, Liu Z, Wang Q, Gao H, Song N, Yang X   +5 more
doaj