Results 301 to 310 of about 5,714,705 (321)
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Microfluidics for single cell analysis
Current Opinion in Biotechnology, 2012Substantial evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their chance of survival. Methods that use average responses from a population often mask the difference from individual cells.
Huabing, Yin, Damian, Marshall
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High-Parameter Single-Cell Analysis
Annual Review of Analytical Chemistry, 2019Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis.
Pratip K, Chattopadhyay +4 more
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Chemical Analysis of Single Cells
Annual Review of Analytical Chemistry, 2008Chemical analysis of single cells requires methods for quickly and quantitatively detecting a diverse array of analytes from extremely small volumes (femtoliters to nanoliters) with very high sensitivity and selectivity. Microelectrophoretic separations, using both traditional capillary electrophoresis and emerging microfluidic methods, are well ...
Laura M, Borland +3 more
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Parallel single‐cell analysis microfluidic platform
ELECTROPHORESIS, 2011AbstractWe report a PDMS microfluidic platform for parallel single‐cell analysis (PaSCAl) as a powerful tool to decipher the heterogeneity found in cell populations. Cells are trapped individually in dedicated pockets, and thereafter, a number of invasive or non‐invasive analysis schemes are performed. First, we report single‐cell trapping in a fast (2–
van den Brink, Floris T.G. +5 more
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Single-cell immune repertoire analysis
Nature MethodsSingle-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. However, it has been extremely challenging to analyze and interpret T cells and B cells and their adaptive
Sergio E. Irac +3 more
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Single‐Cell Transcriptomic Analysis
Comprehensive Physiology, 2020AbstractSingle‐cell sequencing measures the sequence information from individual cells using optimized single‐cell isolation protocols and next‐generation sequencing technologies. Recent advancement in single‐cell sequencing has transformed biomedical research, providing insights into diverse biological processes such as mammalian development, immune ...
Zhihong Zheng +7 more
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Single Cell Analysis of Proteoforms
Journal of Proteome ResearchWe introduce single cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells dropcast onto glass slides. Sampling and detection of whole proteoforms by individual ion mass spectrometry enable a scalable approach to single cell proteomics.
Pei Su +12 more
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Single-Cell Transcriptomic Analysis.
Comprehensive Physiology, 2021Single-cell sequencing measures the sequence information from individual cells using optimized single-cell isolation protocols and next-generation sequencing technologies. Recent advancement in single-cell sequencing has transformed biomedical research, providing insights into diverse biological processes such as mammalian development, immune system ...
Zhihong, Zheng +7 more
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