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Chemical and biological single cell analysis
Current Opinion in Biotechnology, 2010Single cells represent the minimal functional unit of life. A major goal of biology is to understand the mechanisms operating in this minimal unit. Nowadays, analysis of the single cell can be performed at unprecedented resolution using new lab-on-a-chip devices and advanced analytical methods.
A. Schmid +3 more
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Single-Cell Analysis of Mitochondrial DNA [PDF]
, 2015 Understanding the biology of mitochondrial DNA (mtDNA) at the single-cell level has yielded important insights into inheritance, disease, and normal aging. In nuclear gene disorders of mtDNA maintenance, neurodegeneration, and aging, different somatic mtDNA mutations exist within individual cells and may be missed by techniques applied to whole tissue ...
Payne BAI, Cree L, Chinnery PF
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Single-Cell Transcriptomic Analysis.
Comprehensive Physiology, 2020Single-cell sequencing measures the sequence information from individual cells using optimized single-cell isolation protocols and next-generation sequencing technologies. Recent advancement in single-cell sequencing has transformed biomedical research, providing insights into diverse biological processes such as mammalian development, immune system ...
Matthew R. Hodges +8 more
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Microtechnologies and nanotechnologies for single-cell analysis
Current Opinion in Biotechnology, 2004Many efforts are currently underway to try and mimic the properties of single cells with the aim of designing chips that are as efficient as cells. However, cells are nature's nanotechnology engineering at the scale of atoms and molecules, and it might be better to envision a microchip that utilizes a single cell as an experimentation platform. A novel,
Albert van den Berg, Helene Andersson
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Single Cell Analysis of Proteoforms
Journal of Proteome ResearchWe introduce single cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells dropcast onto glass slides. Sampling and detection of whole proteoforms by individual ion mass spectrometry enable a scalable approach to single cell proteomics.
Pei Su +12 more
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Bionanotechnology for single-cell analysis
International Journal of Nanotechnology, 2006The cell is the smallest structural unit of biological life. These microscopic systems perform functions as diverse as energy metabolism, intra- and intercellular signalling by chemical and electrical means, and self-reproduction. Thousands of different biochemical and electrical processes are simultaneously performed with the aid of nanometre-sized ...
Dae Won Moon, Duk Su Koh
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Single-Cell Analysis in Microdroplets
2012The development of microfluidics has steadily increased in the past 20 years and has yielded integrated high-throughput analytical techniques at the microscale, providing novel lab-on-a-chip (LOC) systems to be used for biological and chemical applications [1–5].
Jonathan M. Cooper, Michele Zagnoni
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Microinjection for Single-Cell Analysis
2016The mere existence of life, from unicellular organisms to well-organized multicellular organisms, pathological conditions and death, has always fascinated human beings and demanded understanding of biological systems over several centuries. Further, an efficient treatment strategy for genetic disorders requires understanding of pathological conditions ...
Muniesh Muthaiyan Shanmugam +2 more
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Environmental analysis of single cells
Analytical and Bioanalytical Chemistry, 2006Qiang Zhao, X. Chris Le
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Single‐cell analysis of allergic diseases
Allergy, 2023Mitamura, Yasutaka, Akdis, Cezmi A
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