Results 151 to 160 of about 706,319 (217)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Immune Landscape and Tumour Heterogeneity in Ovarian Cancer: Insights From Single-Cell RNA Sequencing. [PDF]

J Cell Mol Med
Chen S, Elhessewi GMS, Cai H, Alawad WM, Mishra MK, Sayed U.   +5 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Integration of Bulk and Single-Cell RNA Sequencing Analyses in Biomedicine. [PDF]

Int J Mol Sci
Golushko N, Buzdin A.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis. [PDF]

Nat Genet
Krzak M, Alegbe T, Taylor DL, Jones GR, Ghouraba M, Strickland M, Harris BT, Satti R, Arestang K, Ramirez-Navarro L, Nishad N, Cheam KAX, Tutert M, Ozols M, Noell G, Leonard S, Przybilla MJ, Suastegui CR, Khabirova E, Deng T, Najgebauer H, Petrova V, Jones CP, Wana N, Hu MX, Skelton J, Ostermayer J, Gu Y, Garri W, Brezina B, Caballes CQ, Corridoni D, Parkes M, Iyer V, Martin CC, McIntyre RE, Raine T, Anderson CA.   +37 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Single-cell RNA sequencing in ovarian cancer: decoding the tumor microenvironment for personalized therapy. [PDF]

J Ovarian Res
Sayed U, Al-Hasnaawei S, Mohaisen-Mousa H, Jyothi-S R, Priyadarshini-Nayak P, Janney-J B, Singh G, Singh-Chauhan A, Kumar-Mishra M.   +8 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

A single-cell RNA sequencing dataset of cardiac aging in African Turquoise Killifish. [PDF]

Sci Data
Yoon B, Xu Y, Zhu P, Zhang Y, Xu X.
europepmc   +1 more source