Results 91 to 100 of about 731,457 (305)

Leveraging genome wide association studies and single cell RNA sequencing in inflammatory bowel disease

, 2023
In this thesis, the main scientific pursuit is that of leveraging information from genome-wide association studies (GWAS) in combination with gene expression datasets such as to narrow down the list of genes and cell-types that may be important for ...
Voda, Alexandru
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine
Cancer immunotherapy is an innovative treatment approach that leverages the immune system to combat tumors, demonstrating significant therapeutic potential.
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
doaj   +1 more source

Additional file 1 of SMaSH: a scalable, general marker gene identification framework for single-cell RNA-sequencing

, 2022
Additional file 1. Supplementary Material for SMaSH: A scalable, general marker gene identification framework for single-cell RNA ...
S. G. Riva (13218442), M. E. Nelson (13218439), A. Cvejic (13218445)   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Single-cell RNA sequencing of metastatic testicular seminoma reveals the cellular and molecular characteristics of metastatic cell lineage

, 2022
The Single-cell RNA sequencing data of metastatic testicular seminoma, including tumor tissues, pelvic lymph node (LN1) and renal hilus lymph ...
Zhenyuan Yu (6698111)
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Sample Multiplexing for Retinal Single-Cell RNA-Sequencing [PDF]

iScience
Summary Rare cell populations can be challenging to characterize using microfluidic single-cell RNA sequencing (scRNA-seq) platforms. Typically, the population of interest must be enriched and pooled from multiple biological specimens for efficient collection.
Justin Ma, Ting Kuan Chu, Maria Polo Prieto, Yong Park, Yumei Li, Rui Chen, Graeme Mardon, Benjamin J Frankfort, Nicholas M Tran   +8 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Splatter: simulation of single-cell RNA sequencing data

Genome Biology, 2017
As single-cell RNA sequencing (scRNA-seq) technologies have rapidly developed, so have analysis methods. Many methods have been tested, developed, and validated using simulated datasets.
Luke Zappia, Belinda Phipson, Alicia Oshlack   +2 more
doaj   +1 more source