Results 131 to 140 of about 6,439,042 (312)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mode Optimization and Polarization Control in VCSELs with Sub-Wavelength Gratings

IEEE Photonics Journal
We have demonstrated the integration of sub-wavelength gratings (SWG) into a 795 nm vertical cavity surface emitting laser (VCSEL) with inverse surface relief to achieve coordinated control of the mode and polarization. At a grating period of around 0.5 &
Yongli Wang, Chuanchuan Li, Yang Zhang, Jian Li, Xin Wei   +4 more
doaj   +1 more source

Semiconductor filled microstructured optical fibres with single mode guidance

Microstructured optical fibre (MOF) technology has generated new opportunities for the implementation of optical fibres with novel properties and functions [1].
Vukovic, N., Peacock, A.C., Poletti, F., Healy, N.   +3 more
core  

External cavity mode structure of a two-mode VCSEL subject to optical feedback

, 2007
We consider a multi-transverse-mode vertical-cavity surface-emitting laser (VCSEL) subject to optical feedback. The system is modeled by a partial differential equation for the spatial carrier population, which is coupled to delay differential equations ...
Green, K, Krauskopf, B., Lenstra, D., Green, K., Lenstra, D, Krauskopf, B   +5 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Single-Mode-Multimode-Single-Mode Fiber (SMS): Exploring Environmental Sensing Capabilities

IEEE Sensors Letters
In this paper, we study the environmental sensing capabilities of a Single-Mode-Multimode-Single-Mode (SMS) fiber in a simple low-cost configuration. SMS fibers exhibit sensitivity to temperature, humidity, refractive index and strain, making them suitable for numerous applications in telecommunications, environmental monitoring, and more. Experimental
Silvia Diaz, Miguel Ángel Armendáriz, Ignacio R. Matías   +2 more
openaire   +3 more sources