Results 51 to 60 of about 434,799 (299)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

All-Solid Single-Polarization Anti-Resonant Fiber Base on Anisotropic Glass

Photonics, 2023
A single-polarization solid-core anti-resonant fiber is proposed, and the influence of the fiber core material anisotropy of the solid-core anti-resonant fiber on polarization characteristics is investigated using the finite element method.
Weixuan Luo, Bin Zhang, Anping Xiao, Zhiwei Duan, Qiang Ling, Yusheng Zhang, Zhangwei Yu, Zuguang Guan, Daru Chen   +8 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Rare Earth Doped Optical Fibers with Multi-section Core

iScience, 2019
Summary: The gain bandwidth of a single-mode fiber is limited by the atomic transitions of one rare earth gain element. Here we overcome this long-standing challenge by designing a new single-mode fiber with multi-section core, where each section is ...
Chongyuan Huang, Jihong Geng, Tao Luo, Jiali Han, Qing Wang, Rongguang Liang, Shanhui Fan, Shibin Jiang   +7 more
doaj   +1 more source

Comparative study of air-core and coaxial Bragg fibers: single-mode transmission and dispersion characteristics [PDF]

, 2001
Using an asymptotic formalism we developed in an earlier paper, we compare the dispersion properties of the air-core Bragg fiber with those of the coaxial Bragg fiber.
Ouyang, George, Xu, Yong, Yariv, Amnon
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Nano-engineered optical fibers and applications1

Nanophotonics, 2013
The paper reviews optical fibers with nano-engineered features and methods to fabricate them. These optical fibers have nano-engineered regions comprising of randomly distributed voids which provide unique properties for designing next generation of ...
Tandon Pushkar, Li Ming-Jun, Bookbinder Dana C., Logunov Stephan L., Fewkes Edward J.   +4 more
doaj   +1 more source

Miniature High-Sensitivity High-Temperature Fiber Sensor with a Dispersion Compensation Fiber-Based Interferometer [PDF]

, 2009
A miniature high-sensitivity, high-temperature fiber sensor with an interferometer based on a bare small-core-diameter dispersion compensation fiber (DCF) is reported.
Dong, Bo, Wei, Li, Zhou, Da-Peng
core   +2 more sources

Compact and high-performance vortex mode sorter for multi-dimensional multiplexed fiber communication systems [PDF]

, 2020
With the amplitude, time, wavelength/frequency, phase, and polarization/spin parameter dimensions of the light wave/photon almost fully utilized in both classical and quantum photonic information systems, orbital angular momentum (OAM) carried by optical
Chen, Yujie, Chremmos, Ioannis, Liu, Jie, Wen, Yuanhui, Yu, Siyuan, Zhang, Junwei, Zhang, Yanfeng, Zhu, Guoxuan, Zhu, Jiangbo   +8 more
core   +2 more sources