Results 111 to 120 of about 1,193,038 (282)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Spin anisotropy effects in dimer single molecule magnets
, 2006 We present a model of equal spin $s_1$ dimer single molecule magnets. The spins within each dimer interact via the Heisenberg and the most general set of four quadratic anisotropic spin interactions with respective strengths $J$ and $\{J_j\}$, and with ...
A. Bencini +8 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Single‐molecule mass spectrometry
Mass Spectrometry Reviews, 2016 In single‐molecule mass spectrometry, the mass of each ion is measured individually; making it suitable for the analysis of very large, heterogeneous objects that cannot be analyzed by conventional means. A range of single‐molecule mass spectrometry techniques has been developed, including time‐of‐flight with cryogenic detectors, a quadrupole ion trap ...
David Z, Keifer, Martin F, Jarrold
openaire +3 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
eLifeThe HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use.
KM Rifat Faysal +12 more
doaj +1 more source
Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
eLife, 2018 Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a ...
Chantal L Márquez +10 more
doaj +1 more source
Polarization forces in water deduced from single molecule data
, 2004 Intermolecular polarization interactions in water are determined using a minimal atomic multipole model constructed with distributed polarizabilities. Hydrogen bonding and other properties of water-water interactions are reproduced to fine detail by only
A. J. Stone +8 more
core +1 more source
Pulling on single molecules [PDF]
Nature Methods, 2012 Single-molecule methods to apply and measure force and displacement are expanding mechanobiology.
openaire +2 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source