Results 251 to 260 of about 1,193,038 (282)
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Current Opinion in Structural Biology, 2003
Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of ...
Xiaowei, Zhuang, Matthias, Rief
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Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of ...
Xiaowei, Zhuang, Matthias, Rief
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Physical Review Letters, 2004
For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography).
J C H, Spence, R B, Doak
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For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography).
J C H, Spence, R B, Doak
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Annual Review of Physical Chemistry, 2004
▪ Abstract We review recent developments in single-molecule spectroscopy and microscopy. New optical methods provide access to the absorption, emission, or excitation spectra of single nano-objects and can determine either the positions of these objects with subwavelength accuracy or the full three-dimensional orientation of their transition dipole ...
Florian, Kulzer, Michel, Orrit
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▪ Abstract We review recent developments in single-molecule spectroscopy and microscopy. New optical methods provide access to the absorption, emission, or excitation spectra of single nano-objects and can determine either the positions of these objects with subwavelength accuracy or the full three-dimensional orientation of their transition dipole ...
Florian, Kulzer, Michel, Orrit
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Single-Molecule Mechanoenzymatics
Annual Review of Biophysics, 2012The ability of cellular signaling networks to sense, process, and respond to internal and external stimuli relies on their specific detection and transduction based on molecular recognition. The molecular mechanisms by which force is specifically sensed by mechanoenzymatic processes, translated into biochemical signals, and wired to cellular signaling
Elias M, Puchner, Hermann E, Gaub
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Single molecule nanobioscience
Trends in Biochemical Sciences, 2001In recent years, the rapid development and progress of single-molecule detection techniques have opened up a new era of biological research. The advantage of single-molecule studies is that data are not obscured by the ensemble-averaged measurements inherent in classical biochemical experiments.
A, Ishijima, T, Yanagida
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2020
The dielectric nanoparties/molecules in the vicinity of a WGM microcavity evanescently perturb the WGM field. Owing to the tiny mode volume and high quality factor of the microcavity, the resulting resonance shift and spectral broadening of the microcavity’s transmission spectrum can be read out with a high enough signal-to-noise ratio.
Frank Vollmer, Deshui Yu
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The dielectric nanoparties/molecules in the vicinity of a WGM microcavity evanescently perturb the WGM field. Owing to the tiny mode volume and high quality factor of the microcavity, the resulting resonance shift and spectral broadening of the microcavity’s transmission spectrum can be read out with a high enough signal-to-noise ratio.
Frank Vollmer, Deshui Yu
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Nature Nanotechnology, 2017
Mass and electrical charge are fundamental properties of biological macromolecules. Although molecular mass has long been determined with atomic precision, a direct and precise determination of molecular charge remains an outstanding challenge. Here we report high-precision (
Ruggeri Francesca +7 more
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Mass and electrical charge are fundamental properties of biological macromolecules. Although molecular mass has long been determined with atomic precision, a direct and precise determination of molecular charge remains an outstanding challenge. Here we report high-precision (
Ruggeri Francesca +7 more
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Interrogating Single Molecules
Recent Patents on Nanotechnology, 2008The development of nanotechnology relies heavily on the ability to observe and probe at molecular scales. Thus, breakthroughs in instrumentation and techniques play a significant role in the advancement in nanoscience. In this article, we survey recent developments in observing, trapping, and probing single molecules in solution.
Lin, Cong, Alexander D, Wissner-Gross
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Single-Molecule Optoelectronics
Accounts of Chemical Research, 2004With discrete states, several-atom Ag(n) nanoclusters exhibit molecule-like behavior with strong visible fluorescence and robust optical properties. This new class of single-molecule fluorophores has been created and electrically contacted in thin films to produce the first electroluminescent single molecules.
Tae-Hee, Lee +3 more
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Single-Molecule Mechanochemical Sensing
Accounts of Chemical Research, 2022Single-molecule mechanochemical sensing (SMMS) is a novel biosensing technique using mechanical force as a signal transduction mechanism. In the mechanochemical sensing, the chemical binding of an analyte molecule to a sensing template is converted to mechanical signals, such as tensile force, of the template. Since mechanical force can be conveniently
Changpeng Hu, Rabia Tahir, Hanbin Mao
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