Results 231 to 240 of about 6,486,155 (264)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Direct single-molecule visualization of Hsp90-mediated relief of an Hsp70-folding block. [PDF]

Sci Adv
Marzano NR, Skewes B, McMahon S, Rice L, Cox D, van Oijen AM, Ecroyd H.   +6 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Engineering moiré potentials in twisted bilayer MoS₂ for selective single-molecule sensing. [PDF]

Nat Commun
Zhao M, He H, Wang Z, Bai Y, Chang L, Sun L, Wang C, Gao J, Li W, Liu X, Zhang T, Zhang J, Zhang N, Gan L, Liu B, Li J, Terrones M, Lei Y.   +17 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Charge-transfer dynamics in bowl-shaped imide-functionalized corannulenes at ensemble and single-molecule levels. [PDF]

Chem Sci
Thavamani T, Maret PD, T A, Bausback A, Shoyama K, Würthner F, Hariharan M.   +6 more
europepmc   +1 more source

Engineering a Biological Nanopore for Monitoring Protein Dynamics and Conformational Changes at the Single-Molecule Level. [PDF]

ACS Nano
Sarthak K, Van Meervelt V, Soskine M, Maglia G, Aksimentiev A.   +4 more
europepmc   +1 more source

Profiling Protein Aggregate Size Using Single-Molecule Array Technology. [PDF]

Anal Chem
Böken D, Wu Y, Zhang J, Xia Z, Beltran-Lobo P, Croft CL, Weerasekera S, Heslegrave A, Zetterberg H, Keshavan A, Schott JM, Jimenez-Sanchez M, Duffy DC, Klenerman D.   +13 more
europepmc   +1 more source

Interrogating nanopores with light: optipore sensing for single molecule analyses. [PDF]

J Nanobiotechnology
Verma NC, Soni N, Meller A.
europepmc   +1 more source

Antiaromaticity-Driven Enhancement of Single-Molecule Electrical Conductance by s-Indacene Molecular Bridges. [PDF]

Angew Chem Int Ed Engl
Chu CP, Hanamura Y, Ohto T, Maeda S, Yamada R, Yu SL, Cheng YJ, Tada H, Tobe Y.   +8 more
europepmc   +1 more source