Results 91 to 100 of about 730,667 (367)

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout

Arthritis Care &Research, Accepted Article.
Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome.
Saw Thu Wah, Hathairad Hananantachai, Jintana Patarapotikul, Jun Ohashi, Izumi Naka, Pornlada Nuchnoi   +5 more
doaj   +1 more source

Picking single-nucleotide polymorphisms in forests [PDF]

BMC Proceedings, 2007
Abstract With the development of high-throughput single-nucleotide polymorphism (SNP) technologies, the vast number of SNPs in smaller samples poses a challenge to the application of classical statistical procedures. A possible solution is to use a two-stage approach for case-control data in which, in the first stage, a screening test selects
Schwarz, Daniel F, Szymczak, Silke, Ziegler, Andreas, König, Inke R   +3 more
openaire   +2 more sources

Validation of a Genetic Risk Score Combined with Clinical Variables for Predicting Pulmonary Fibrosis in early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objectives Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). The study aimed to externally validate a genetic risk score (GRS) and a combined risk score for predicting the risk of RA‐associated PF in an independent cohort of early‐RA patients. Methods This study utilized an inception cohort of 1118 patients
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]

, 2019
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G, Biswas, Nilima, González-Sarmiento, Rogelio, Hightower, C Makena, Ichinose, Hiroshi, Kurosaki, Hiroki, León-Jiménez, David, Lipkowitz, Michael S, Mahata, Manjula, Miramontes-Gonzalez, Jose Pablo, Nievergelt, Caroline M, O'Connor, Daniel T, Schork, Andrew J, Vaingankar, Sucheta, Zhang, Kuixing, Ziegler, Michael G   +15 more
core   +2 more sources

A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria [PDF]

, 2022
Sien Lequeue, Jessie Neuckermans, Ine Nulmans, Ulrich Schwaneberg, Tamara Vanhaecke, Joery De Kock   +5 more
openalex   +1 more source

Estimating Additive and Non-Additive Genetic Variances and Predicting Genetic Merits Using Genome-Wide Dense Single Nucleotide Polymorphism Markers

PLoS ONE, 2012
Non-additive genetic variation is usually ignored when genome-wide markers are used to study the genetic architecture and genomic prediction of complex traits in human, wild life, model organisms or farm animals. However, non-additive genetic effects may
G. Su, O. F. Christensen, T. Ostersen, M. Henryon, M. Lund   +4 more
semanticscholar   +1 more source

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

Advanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi, Jorge Romero Domínguez, Erol Hasan, Temur Maksudov, Thomas D. Anthopoulos, Dana Alsulaiman   +5 more
wiley   +1 more source

Association of rs2075650 polymorphism of tomm40 gene with type 2 diabetes in Dilijan city, Iran [PDF]

مجله علوم پزشکی فیض (پیوسته), 2023
Background and Aim: The tomm40 gene encodes the Tomm40 protein, which is a translocase in the mitochondrial outer membrane. Changes in the tomm40 gene can lead to mitochondrial dysfunction. In this study, the association between rs2075650 polymorphism of
Maryam Salavatifar, Parya Ahmadzadeh Irandoust, Faranak Jamshidian   +2 more
doaj  

A new and versatile method for the successful conversion of AFLP-TM markers into simple single locus markers [PDF]

, 2003
Genetic markers can efficiently be obtained by using amplified fragment length polymorphism (AFLP) fingerprinting because no prior information on DNA sequence is required.
Brugmans, B.W., Eck, H., van, Hulst, R.G.M., van der, Lindhout, W.H., Visser, R.G.F.   +4 more
core   +2 more sources