Results 91 to 100 of about 5,748,368 (263)

Scale for methodologic Quality Assessment of the Single Nucleotide Polymorphism association studies of IBD.

, 2015
Scale for methodologic Quality Assessment of the Single Nucleotide Polymorphism association studies of IBD.
Side Liu (428794), Yang Cheng (125394), Yun Zhu (46269), Wei Zhang (405), Xiuping Huang (747117), Zelong Han (747118)   +5 more
core   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Human Brain Single Nucleotide Polymorphism: Validation of DNA Sequencing

Journal of Alzheimer's Disease Reports, 2018
Genetic factors may be involved in the onset of neurodegenerative diseases like Alzheimer’s disease. In the case of the familial type, the disease is due to an inherited mutation at specific sites in three genes. Also, there are some genetic risk factors
Ángel J. Picher, Félix Hernández, Bettina Budeus, Eduardo Soriano, Jesús Avila   +4 more
doaj   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Single nucleotide polymorphism (SNP) association analysis comparing IBD patients with control.

, 2019
Single nucleotide polymorphism (SNP) association analysis comparing IBD patients with control.
Walter A. Koltun (243529), Xuemei Huang (170562), Lijun Zhang (483325), Kent E. Vrana (6411005), Eugene Gonzalez-Lopez (6410996), Yuka Kawasawa-Imamura (6410999), Matthew D. Coates (6411002)   +6 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome.

PLoS ONE, 2019
IntroductionInterstitial Cystitis (IC) is a chronic condition diagnosed based on the presence of symptoms, such as suprapubic/ pelvic pain, pressure or discomfort in association with urgency and increased urinary frequency.
Valter D Cassão, Sabrina T Reis, Ruan Pimenta, Marcos Lucon, Katia R M Leite, Miguel Srougi, Homero Bruschini   +6 more
doaj   +1 more source

DNAzyme based gap-LCR detection of single-nucleotide polymorphism

, 2013
Fast and accurate detection of single-nucleotide polymorphism (SNP) is thought more and more important for understanding of human physiology and elucidating the molecular based diseases.
Du, F, Zhao, YY, Yameen, A, Chen, HD, Zhou, L, Tang, Z   +5 more
core  

Additional single-nucleotide polymorphism markers at the 92 unambiguously inferred haplotypes in this study.

, 2016
Additional single-nucleotide polymorphism markers at the 92 unambiguously inferred haplotypes in this study.
Petr Jarolim (3391775), Krystyna H. Chrzanowska (92987), Kathrin Saar (167338), André Reis (166910), Mohsen Karbasiyan (251875), Karl Sperling (50312), Michael Krawczak (77525), Michael Nothnagel (69111), Eva Seemanova (3391784), Ivo Barić (3179835), Igor Resnick (3391778), Mustafa Tekin (114701), Ivo Kremensky (3320940), Katrin Hoffmann (17460), Pavel Seeman (699750), Peter Kovacs (103720), Véronique Dutrannoy (253124), Martin Digweed (264457), Jan Vejvalka (3391781), Mehdi Ghani (3391772), Raymonda Varon (50311)   +20 more
core   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source