Results 171 to 180 of about 5,748,368 (263)

Single Nucleotide Polymorphism at the LGB gene of the Italian Mediterranean River Buffalo.

, 2011
Identification and characterization of Single Nucleotide Polymorphism at the LGB (beta-lactoglobulin) gene of the Italian Mediterranean River ...
PAUCIULLO A., DI BERARDINO, DINO, RAMUNNO, LUIGI, COSENZA, GIANFRANCO   +3 more
core  

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Direct single-nucleotide polymorphism genotyping from whole blood without DNA extraction. [PDF]

J Equine Sci
Furukawa R, Tozaki T, Kawate K, Kikuchi M, Ishige T, Fukui E, Kakoi H.   +6 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Association of the TSHR Gene Intronic Single Nucleotide Polymorphism rs2268458 With Non-autoimmune Hypothyroidism: A Hospital-Based Cross-Sectional Study. [PDF]

Cureus
Usha Rani M, Vemparala SS, Pakalapati S, Varma Lakkamraju D.   +3 more
europepmc   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Single-Nucleotide Polymorphism (SNP) c.73G>A in the UBC9 (E2) SUMO Gene and Breast Cancer Risk in Polish Women. [PDF]

Cancers (Basel)
Romanowicz H, Sychowski G, Kalinowski S, Sypniewski S, Zakharin O, Zadrożny M, Łukasiewicz H, Samulak D, Smolarz B.   +8 more
europepmc   +1 more source

Dietary Artificial Sweeteners: From Chemical Transformation in Food to Gut Microbial Processing

ChemFoodChem, EarlyView.
This review article unites classical and recent findings on the stability of artificial sweeteners in food. The focus is on ten sweeteners approved in the European Union: their chemical stability during processing and storage, individual degradation products, and their interactions with the intestinal microbiota.
Jürgen Lassak, Michael Hellwig
wiley   +1 more source

Results from the VANISH study: A prospective multicenter study validating a single-nucleotide polymorphism-based noninvasive prenatal test to assess aneuploidy risk in surviving twins of vanishing twin pregnancies. [PDF]

Pregnancy (Hoboken)
Dugoff L, Mumford SL, Rochon ML, Chavez M, Kohari K, Scholl JE, Berkin JA, Roman AS, Chueh J, Wolf SB, Palomares KTS, Hurt KJ, Wapner RJ, Gorman K, Wick MJ, Savasan ZA, Platt LD, Treadwell MC, Al-Khan A, Livingston JM, Hoffman MK, Rabin-Havt SS, Rabinowitz M, Ahmed E, Saben JL, Sun N, Butskova A, Xu W, Meltzer J, Souter V.   +29 more
europepmc   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source