Results 261 to 270 of about 746,762 (326)

Analysis of runs of homozygosity in Yeonsan Ogye chickens using 600K single nucleotide polymorphism arrays. [PDF]

J Anim Sci Technol
Kim J, Kim M, Cho E, Lee SS, Kim S, Jin D, Lee JH.   +6 more
europepmc   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Role of single-nucleotide polymorphism microarray in the classification of BAP1-inactivated melanocytic tumours. [PDF]

Histopathology
Durgin JS, Zoumberos NA, Novice T, Fullen DR, Hristov AC, Lowe L, Patel RM, Harms PW, Andea AA, Bresler SC.   +9 more
europepmc   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Clinical Impact of CTLA-4 Single-Nucleotide Polymorphism in DLBCL Patients Treated with CAR-T Cell Therapy. [PDF]

Curr Oncol
Seipel K, Shaforostova I, Nilius H, Bacher U, Pabst T.   +4 more
europepmc   +1 more source

Exploring the Relationship Between MDM4 Gene Polymorphisms (rs1380576 and rs4245739) and Breast Cancer Susceptibility in Bangladesh: A Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Our findings indicated that the rs4245739 A>C polymorphism was not associated with BC risk in the Bangladeshi population, whereas the rs1380576 C>G polymorphism was significantly associated with BC risk. This study provides new insights into the genetic factors influencing breast cancer susceptibility in the Bangladeshi population, highlighting the ...
J. M. Aousiful Islam, Sharif Ahamed, Shafiqul Islam, M. Mahboob Hossain, Md Sadbean Hossain, Md. Shaki Mostaid, Md. Rabiul Islam, Md. Aminul Haque   +7 more
wiley   +1 more source

Association of <i>FAM13A</i> single-nucleotide polymorphism with spirometry indices and pulmonary ventilation characteristics in patients with chronic obstructive pulmonary disease. [PDF]

J Int Med Res
Nguyen BH, Tran NTC, Ho CQ, Tran TTT, Phan HN, Tran V, Pham NTN, Nguyen KT, Pham KH.   +8 more
europepmc   +1 more source

UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a PCR‐based fragment analysis assay for UGT1A1 rs3064744 targeting TA5 (*36), TA6 (*1), TA7 (*28), and TA8 (*37). The assay was CLIA validated with data showing 100% concordance and a sensitivity of 0.5 ng/uL. The assay was then implemented in a patient cohort of n = 940 and the results compared with PharmacoScan.
Ryan N. Baugher, Kristen M. Pike, Teri M. Plona, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Stephen M. Hewitt   +6 more
wiley   +1 more source

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans. [PDF]

Front Pharmacol
Park JW, Kim JM, Bang YY, Kim KA, Yu S, Park JY.   +5 more
europepmc   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, EarlyView.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source