Results 131 to 140 of about 165,721 (244)

Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathy. [PDF]

iScience
Simonson B, Chaffin M, Guedira Y, Choudhury TZ, Xiao L, Ruan R, Schneider K, Morris J, Koledova V, Bedi KC, Margulies KB, Klattenhoff C, Ellinor PT.   +12 more
europepmc   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Single Nucleus RNA Sequencing of Presumed Human Heart Failure Myocardium

Journal of Molecular and Cellular Cardiology Plus
Deborah Eaton, Kenneth Bedi, Ryan Pfeiffer, Nathan Tucker, Kenneth Margulies   +4 more
doaj   +1 more source

Single-Nucleus RNA Sequencing Highlights Endothelial and Müller Cell ER Stress During Retinal Neovascularization in Vldlr-/- Mouse. [PDF]

Invest Ophthalmol Vis Sci
Galdamez A, Park S, Temme W, Bradley A, Stevenson E, Chea L, Lee EJ, Lin JH.   +7 more
europepmc   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Nuclei Isolation on Murine DRG for Single Nucleus RNA Sequencing v1

This is a fast and reproducible method for nuclei isolation on murine dorsal root ganglia for downstream single nuclei RNA sequencing. This protocol utilizes the Nuclei Extraction Buffer, Anti-Nucleus Microbeads, gentleMACS Octo Dissociator, and Octo Coolers from Miltenyi Biotec for standardization and ease of use.
Julia Younis, Ismail Yaman, Mira Jeong, Luis Tovias, Jiansen Yan, Brendan Lee, Nele Haelterman   +6 more
openaire   +1 more source

Protocol for classifying cellular senescence from single-cell and single-nucleus RNA sequencing data. [PDF]

STAR Protoc
Lund AN, Thompson RC, Kopell BH, Nadkarni GN, Nestler EJ, Schadt EE, Charney AW, Beckmann ND.   +7 more
europepmc   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Single-nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia. [PDF]

Clin Transl Med
Zeng Q, Zhu F, Cao D, Sun Y, Li L, Tan Z, Li C, Ren X, Liu Y, Lin Z, Zou D.   +10 more
europepmc   +1 more source