Results 211 to 220 of about 165,721 (244)

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Single nucleus RNA sequencing unveils relationship between microglia and endothelial cells in mixed Alzheimer's disease and vascular pathology. [PDF]

Neurobiol Dis
Olayinka OA, O'Neill N, Empawi JA, Bock P, Hu J, Rickner H, Wong M, Stein TD, Wolozin B, Farrer LA, Zhang X.   +10 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Single-nucleus RNA sequencing reveals GABAergic vulnerability and reactive gliosis driven by loss of TDP-43. [PDF]

iScience
Thapa R, Adhikari N, Gautam S, Sun M, McOmie S, Davydzenka V, Smith D, Syring J, Kaligis H, Kosmicki JM, Chen R, Li Y.   +11 more
europepmc   +1 more source

Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAF^V600E-negative gangliogliomas. [PDF]

Brain Commun
Cases-Cunillera S, Müller P, van Waardenberg AJ, Schoch S, Huberfeld G, Höllig A, Delev D, Hamed M, Becker AJ, van Loo KMJ.   +9 more
europepmc   +1 more source

Single-nucleus RNA-sequencing reveals the cellular programs driving nematode-induced giant cell formation in tomato. [PDF]

Hortic Res
Zadegan SB, Li P, Sultana MS, Abbas HMK, Coffey N, Öztürk C, Elwasif M, Rice JH, Krishnan HB, Hewezi T.   +9 more
europepmc   +1 more source

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Nature Biotechnology, 2020
The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly in recent years, enabling major discoveries and large-scale cell mapping efforts. However, these methods have not been systematically and comprehensively benchmarked.
Alex K. Shalek, Amanda Kedaigle, Orit Rozenblatt-Rosen   +2 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

Plant Nuclei Isolation for Single-Nucleus RNA Sequencing

2023
Transcriptome profiling has been significantly hampered by the heterogeneity among individual cells within a tissue or an organ. Recent advances in single cell transcriptome profiling have significantly advanced our understanding of the transcriptome. However, plant single-cell RNA sequencing (scRNA-seq) relies on the isolation of protoplasts, which is
Xu, Xin, Fei, Du, Yuling, Jiao
openaire   +2 more sources

Multiplexed Single‐Nucleus RNA Sequencing Using Lipid‐Oligo Barcodes

Current Protocols, 2022
AbstractThis protocol describes a robust pipeline for simultaneously analyzing multiple samples by single‐nucleus (sn)RNA‐seq. cDNA obtained from each single sample are labeled with the same lipid‐coupled oligonucleotide barcode (10X Genomics). Nuclei from as many as 12 individual samples can be pooled together and simultaneously processed for cDNA ...
Qi, Zhang, Seong Won, Kim, Joshua M, Gorham, Daniel M, DeLaughter, Tarsha, Ward, Christine E, Seidman, Jonathan G, Seidman   +6 more
openaire   +2 more sources