Results 91 to 100 of about 2,892,749 (302)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A minimal model for congestion phenomena on complex networks
, 2009 We study a minimal model of traffic flows in complex networks, simple enough to get analytical results, but with a very rich phenomenology, presenting continuous, discontinuous as well as hybrid phase transitions between a free-flow phase and a congested
+20 more
core +1 more source
Journal of Applied Fluid Mechanics, 2015 The pulsatile flow of blood in narrow arteries with multiple-stenoses under body acceleration is analyzed mathematically, treating blood as (i) single-phase Herschel-Bulkley fluid model and (ii) two-phase Herschel- Bulkley fluid model.
DS Sankar, Atulya K Nagar, A Vanav kumar
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Laminar flow of two miscible fluids in a simple network
, 2012 When a fluid comprised of multiple phases or constituents flows through a network, non-linear phenomena such as multiple stable equilibrium states and spontaneous oscillations can occur.
Azzopardi B. J. +10 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2000 We study the steady-state behavior of a driven non-equilibrium lattice gas of hard-core particles with next-nearest-neighbor interaction. We calculate the exact stationary distribution of the periodic system and for a particular line in the phase diagram
A. B. Kolomeisky +45 more
core +1 more source
Direct Cooling of Microsystems Using a Two-Phase Microfluidic Droplet
ComputationDroplet-based microfluidics offers a promising approach for enhancing heat transfer in microchannels, which is critical for the thermal management of microsystems.
Wenpei Lu +3 more
doaj +1 more source
Effects of Flow Regimes on Maximum Pressure in Offshore Pipelines [PDF]
مهندسی منابع آب, 2019 One of the most important factors in pipeline hydraulics and its protection against probable damages is keeping the pressure in a specific limit and also knowing how the pressure functions in the pipe through the pipeline route.
Zahra Ghadampour, Mohammad sadegh Narges
doaj