Results 71 to 80 of about 944,762 (268)
Direct Cooling of Microsystems Using a Two-Phase Microfluidic Droplet
ComputationDroplet-based microfluidics offers a promising approach for enhancing heat transfer in microchannels, which is critical for the thermal management of microsystems.
Wenpei Lu +3 more
doaj +1 more source
Effects of Flow Regimes on Maximum Pressure in Offshore Pipelines [PDF]
مهندسی منابع آب, 2019 One of the most important factors in pipeline hydraulics and its protection against probable damages is keeping the pressure in a specific limit and also knowing how the pressure functions in the pipe through the pipeline route.
Zahra Ghadampour, Mohammad sadegh Narges
doaj
MATEC Web of Conferences, 2016 Turbulent droplet-laden flow downstream of a sudden pipe expansion is numerically studied using Eulerian two-fluid model. The model is used to investigate the effect of droplet evaporation on the particle dispersion and on the gas phase turbulence ...
Pakhomov Maksim, Terekhov Viktor
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Research Progress of Microchannel Heat Sink Structures Based on Single-Phase Flow
Zhileng xuebaoMicrochannel cooling, with its high heat transfer efficiency, low thermal resistance, and light weight advantages, is one of the most effective technologies for solving the problem of heat dissipation with high heat flux; however, it faces the issue of ...
Zhao Jie, Cui Xiaoyu
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source