Results 51 to 60 of about 944,762 (268)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Single- and two-phase flow model in low-permeability reservoir
Petroleum, 2019 In petroleum development, low-permeability reservoir means having permeability of porous media lower than 50 micro-Darcy. The mathematical model of liquid flow in low-permeability reservoirs has been difficult to describe for a long time, and an ideal ...
Song Fuquan +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Energies, 2018 The paper presents experimental and numerical investigations performed on a single stage, single-suction, horizontal-orientated centrifugal pump in air–water two-phase non-condensable flow conditions.
Qiaorui Si +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Flow and heat transfer in a closed loop thermosyphon. Part I – theoretical simulation
Journal of Energy in Southern Africa, 2017 A natural circulation, closed loop thermosyphon can transfer heat over relatively large distances without any moving parts such as pumps and active controls.
R.T. Dobson, J.C. Ruppersberg
doaj +1 more source
An Experimental Study on Coal Fines Migration during Single Phase Water Flow
Geofluids, 2020 Coal fines migration and intrusion in coal fractures affect coalbed methane (CBM) wells performance by reducing reservoir permeability and production continuity. Physical simulations are conducted to investigate the permeability variation under different
Wenlong Han +5 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Effect of sand particles on flow structure of free jet from a nozzle
Journal of Mechanical Engineering and Sciences, 2019 The Characteristics of single and two- phase flow from a circular turbulent free jet from a nozzle of 10 mm diameter were investigated experimentally and numerically. The measurements were conducted for ReJ = 10007 - 31561.
M. J. Al-Dulaimi +3 more
doaj +1 more source