Results 61 to 70 of about 12,050,971 (277)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Single- and two-phase flow model in low-permeability reservoir

Petroleum, 2019
In petroleum development, low-permeability reservoir means having permeability of porous media lower than 50 micro-Darcy. The mathematical model of liquid flow in low-permeability reservoirs has been difficult to describe for a long time, and an ideal ...
Song Fuquan, Song Xingxing, Wang Yong, Sun Yeheng   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigation on the Handling Ability of Centrifugal Pumps under Air–Water Two-Phase Inflow: Model and Experimental Validation

Energies, 2018
The paper presents experimental and numerical investigations performed on a single stage, single-suction, horizontal-orientated centrifugal pump in air–water two-phase non-condensable flow conditions.
Qiaorui Si, Gérard Bois, Qifeng Jiang, Wenting He, Asad Ali, Shouqi Yuan   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of sand particles on flow structure of free jet from a nozzle

Journal of Mechanical Engineering and Sciences, 2019
The Characteristics of single and two- phase flow from a circular turbulent free jet from a nozzle of 10 mm diameter were investigated experimentally and numerically. The measurements were conducted for ReJ = 10007 - 31561.
M. J. Al-Dulaimi, F. A. Hamad, A. A. Abdul Rasool, K. A. Ameen   +3 more
doaj   +1 more source

An Experimental Study on Coal Fines Migration during Single Phase Water Flow

Geofluids, 2020
Coal fines migration and intrusion in coal fractures affect coalbed methane (CBM) wells performance by reducing reservoir permeability and production continuity. Physical simulations are conducted to investigate the permeability variation under different
Wenlong Han, Yanbin Wang, Jingjing Fan, Yong Li, Xiang Wu, Yun Yu   +5 more
doaj   +1 more source