Results 81 to 90 of about 252,475 (273)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Modelling and Simulation of Mho Type Distance Relay for High Voltage Transmission Line Protection Using MATLAB Software

open access: yesJAREE (Journal on Advanced Research in Electrical Engineering), 2019
Transmission lines are an important part of a power system. Transmission lines have high power transmission capacity and they are prone to faults of larger magnitudes. Various faults occur in transmission lines. Therefore, protection relays are necessary
win win tun, Ohn Zin Lin, Han Su Yin
doaj   +1 more source

Seismic reliability assessment of classical columns subjected to near-fault ground motions [PDF]

open access: yes, 2013
A methodology for the performance-based seismic risk assessment of classical columns is presented. Despite their apparent instability, classical columns are, in general, earthquake resistant, as proven from the fact that many classical monuments have ...
Fragiadakis, Michalis   +2 more
core   +5 more sources

FEATURES OF A FAULTY PHASE AT SINGLE PHASE-TO-GROUND FAULTS

open access: yesElectrical and data processing facilities and systems, 2022
Relevance Devices for determining the location of fault on power lines assume a known type of short circuit and faulty phases. However, their algorithms, as a rule, can not distinguish the faulty phase. Therefore, the determination of faulty phases during short circuits on power lines is performed by separate devices – faulty phase selectors.
Vitaly Shabanov, Alexander Sorokin
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Layered architecture for quantum computing

open access: yes, 2012
We develop a layered quantum computer architecture, which is a systematic framework for tackling the individual challenges of developing a quantum computer while constructing a cohesive device design.
Alexei Yu. Kitaev   +23 more
core   +4 more sources

Geometry optimization of dry ice blasting nozzle for the noise reduction using experimental validation [PDF]

open access: yes, 2019
Dry ice blasting provides many advantages to surface cleaning in which the blasting medium sublimate during the surface impact will not leave a secondary contamination.
Mat, Mohamad Nur Hidayat
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Algorithm for single phase-to-ground fault digital distance relay

open access: yesIET Generation, Transmission & Distribution, 2012
The value of the potential that appears at the fault location during a ground fault at a high-voltage overhead line depends on many different factors and cannot be considered as an a priori known quantity. Owing to this, the influence of this quantity on the current and voltage measured at one of the line terminals is also unknown so the fault distance
openaire   +1 more source

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