Results 61 to 70 of about 253,400 (298)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hybrid protection algorithm for power system with renewable energy generation using Stockwell transform and Wigner distribution function

The Journal of Engineering, 2022
Rapid technological development in grid integration of renewable energy (RE) plants has increased the RE penetration level in power utility network. This dramatic change in power scenario challenges the protection and stability of grid.
Om Prakash Mahela, Mukesh Kumar Gupta, Atul Kulshrestha, Baseem Khan, Rajendra Mahla, Akhil Ranjan Garg, Aditya R. Gautam, Sanjeevikumar Padmanaban   +7 more
doaj   +1 more source

Research on selective leakage protection of 10 kV system based on transient characteristic parameters in coal mine

Meikuang Anquan, 2022
When a single-phase grounding fault occurs in the coal mine 10 kV power supply system, due to the low sampling frequency of the system, the traditional transient line selection method is easy to lose the “line selection information”, and is greatly ...
GUO Runshou, CAO Jiyuan
doaj   +1 more source

Cooperative Virtual Sensor for Fault Detection and Identification in Multi-UAV Applications [PDF]

, 2018
This paper considers the problem of fault detection and identification (FDI) in applications carried out by a group of unmanned aerial vehicles (UAVs) with visual cameras.
Heredia Benot, Guillermo, Ollero Baturone, Aníbal, Suárez, Alejandro   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Traveling-Wave Based Fault Location for Phase-to-Ground Fault in Non-Effectively Earthed Distribution Networks

Energies, 2020
This paper presents a multi-terminal traveling-wave-based fault location method for phase-to-ground fault in non-effectively earthed distribution systems.
Yani Wang, Tao Zheng, Chang Yang, Li Yu
doaj   +1 more source

Analisa Gangguan Satu Fasa Ke Tanah Yang Mengakibatkan Sympathetic Trip Pada Penyulang Yang Tidak Terganggu Di PLN APJ Surabaya Selatan [PDF]

, 2006
Twenty kilovolts power distribution network system at East Java use high resistance (500 ?) grounding system that makes maximum single phase to ground fault current 25 Amperes. To detect this fault current, a Directional Ground Relay (DGR) is used.
Kongdoro, R. (Rusli), Machmudsyah, T. (Tabrani), Setiadji, J. S. (Julius)   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combined line selection of single-phase grounding faults considering harmonic injection of distributed powers

电力工程技术, 2023
With the improvement of the requirements for the safe operation of distribution network lines, the harmonics injected by distributed power generation make the existing line selection methods ineffective, and the fault line selection method with a single ...
LI Yan, ZHAO Ying, DU Lei, XU Tianqi, TIAN Ye   +4 more
doaj   +1 more source