Results 61 to 70 of about 10,043 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Distribution Network Voltage Arc Suppression Method Based on Flexible Regulation of Neutral Point Potential of the New Grounding Transformer

Frontiers in Energy Research, 2022
Aiming at the problems that the existing arc suppression cabinet technology cannot adjust the zero sequence voltage flexibly and the control and hardware implementation of active arc suppression equipment based on power electronics are difficult, a new ...
Wu Lifang, Bai Hao, Zhou Ke, Yuan Zhiyong, Yu Xiaoyong, Lei Jinyong, Zou Yu, Zhang Yuan   +7 more
doaj   +1 more source

A NOVEL LOGIC TO STATOR SINGLE PHASE - TO - GROUND FAULT FOR POWER-FORMER

, 2021
The stator single-phase to ground fault is one of the most common fault that a Generator will suffer. If such fault is neglected then there are chances of converting it into phase to phase fault.
CHIRRA ANITHA, SHAKIL D. JAMADAR, AKIREDDY SHRAVANKUMAR   +2 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research on selective leakage protection of 10 kV system based on transient characteristic parameters in coal mine

Meikuang Anquan, 2022
When a single-phase grounding fault occurs in the coal mine 10 kV power supply system, due to the low sampling frequency of the system, the traditional transient line selection method is easy to lose the “line selection information”, and is greatly ...
GUO Runshou, CAO Jiyuan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Hybrid protection algorithm for power system with renewable energy generation using Stockwell transform and Wigner distribution function

The Journal of Engineering, 2022
Rapid technological development in grid integration of renewable energy (RE) plants has increased the RE penetration level in power utility network. This dramatic change in power scenario challenges the protection and stability of grid.
Om Prakash Mahela, Mukesh Kumar Gupta, Atul Kulshrestha, Baseem Khan, Rajendra Mahla, Akhil Ranjan Garg, Aditya R. Gautam, Sanjeevikumar Padmanaban   +7 more
doaj   +1 more source

Combined line selection of single-phase grounding faults considering harmonic injection of distributed powers

电力工程技术, 2023
With the improvement of the requirements for the safe operation of distribution network lines, the harmonics injected by distributed power generation make the existing line selection methods ineffective, and the fault line selection method with a single ...
LI Yan, ZHAO Ying, DU Lei, XU Tianqi, TIAN Ye   +4 more
doaj   +1 more source