Results 51 to 60 of about 32,629 (363)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Single-Phase Nine-Level Boost Inverter
Energies, 2019 A novel single-phase nine-level boost inverter is proposed in this paper. The proposed inverter has an output voltage which is higher than the input voltage by switching capacitors in series and in parallel.
Dai-Van Vo +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Synchronization Method for Single-Phase Grid-Tied Inverters [PDF]
IEEE Transactions on Power Electronics, 2016 The controllers of single-phase grid-tied inverters require improvements to enable distribution generation systems to meet the grid codes/standards with respect to power quality and the fault ride through capability. In that case, the response of the selected synchronization technique is crucial for the performance of the entire grid-tied inverter.
Hadjidemetriou, L. +7 more
openaire +3 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Novel Single-Stage Electrolytic Capacitor-Less Buck-Boost Inverter
EnergiesNowadays, single-phase, single-stage, buck-boost power inverters are mostly considered to be used for renewable energy source applications due to their wide range of capabilities.
Youn-Ok Choi, Khai M. Nguyen
doaj +1 more source
A new single‐phase multilevel inverter with improved modulation technique [PDF]
, 2023 Bhukya Nageswar Rao +4 more
openalex +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Design And Implementation Of Single Phase Inverter
, 2017 Now a days due to industrialization, there is gap between demand and supply, therefore the need of electricity is increased and we use the electricity efficiently. We cannot store the electricity in AC form, so we store the energy in battery in the form of DC and then it converts into AC using inverter.
PROF. A. N. WADEKAR +4 more
openaire +2 more sources