Results 61 to 70 of about 66,959 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Microcontroller Based Variable Frequency Power Inverter [PDF]

, 2007
The variable frequency inverters have been used in wide applications, such as speed control of induction motors. The variable speed operation of a single phase and three-phase induction motors suffer from large harmonic and limited speed range. Therefore,
A. Ahmed, Khalid Ali Madi
core  

A Fault-Tolerant Two-Motor Drive With FCS-MP-Based Flux and Torque Control [PDF]

, 2014
Independently controlled multi-motor drives are typically realized by using a common dc link and independent sets of three-phase inverters and motors. In the case of an open-circuit fault in an inverter leg, one motor becomes single-phase.
Abd Rahim, N, Hew, W-P, Jones, M, Levi, E, Lim, C-S   +4 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Novel Single-Stage Electrolytic Capacitor-Less Buck-Boost Inverter

Energies
Nowadays, single-phase, single-stage, buck-boost power inverters are mostly considered to be used for renewable energy source applications due to their wide range of capabilities.
Youn-Ok Choi, Khai M. Nguyen
doaj   +1 more source

RANCANG BANGUN INVERTER JEMBATAN PENUH FASA TUNGGAL DENGAN TAPIS LC [PDF]

, 2016
Dalam lima tahun belakangan ini, inverter fasa tunggal telah digunakan dalam banyak jenis aplikasi seperti UPS, konversi energi terbarukan, dan catu daya.
Wijaya, Fajar Witama
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An efficient power decoupling topology circuit based on a novel three-port three-switches flyback series circuit.

PLoS ONE
Both filter inductors, electrolytic capacitors, and radiators play a significant role in the inverter of a PV (Photovoltaic) power generation system. These three parts are the largest in an inverter, which affects the performance of the inverter.
Wang Jinpeng, Kang Yufang, Yao Qingxue, Jeremy Gillbanks, Zhao Xin   +4 more
doaj   +1 more source