Results 101 to 110 of about 858,505 (337)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Investigation оf Microprocessor Differential Protection оf Power Reducing Transformer

open access: yesНаука и техника, 2014
The paper presents investigations on functioning of a differential protection of 110 kV reducing transformer  with internal faults using computer simulation.
F. A. Romaniuk, M. S. Loman
doaj  

Low-Frequency Transient Model of Single-Phase Four-Limb Converter Transformer Considering the Nonlinear Excitation Characteristics of the Iron Core

open access: yesApplied Sciences
Transformer modeling is a crucial method for analyzing transient phenomena such as inrush currents. The primary characteristic of a transformer transient model is its ability to reflect how the transformer’s structure and material properties influence ...
Xichen Pei   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Development of an Electromagnetic‐Thermal Circuit Model for Single‐Phase Three‐Limb Transformers

open access: yesHigh Voltage
Analysing the heat states of transformers under DC bias requires careful consideration of their own structural and material characteristics. Although the 3D finite element method (FEM) is a reliable way of simulating all the details of transformers, it ...
Yidan Hu   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Smart grids for rural conditions and e-mobility - Applying power routers, batteries and virtual power plants [PDF]

open access: yes, 2016
Significant reductions of greenhouse gas emission by use of renewable energy sources belong to the common targets of the European Union. Smart grids address intelligent use and integration of conventional and renewable generation in combination with ...
Boehner, Volker   +6 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A Direct Power Feeding System for AC Railway Networks Using Modular Multilevel Converter [PDF]

open access: yesInternational Journal of Railway Research, 2018
Traditional railway power supply systems impose substantial power quality problems (PQ) on the utility network, such as unbalance, harmonics and a large amount of reactive power. This paper proposes a topology based on three-phase to single-phase modular
Hamed Jafari Kaleybar   +4 more
doaj  

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