Results 91 to 100 of about 19,320,706 (242)

The behavior of statically-indeterminate structural members and frames with cracks present [PDF]

, 2009
Arts et Métiers ParisTech, invitation en tant que professeur invité de Paul C. Paris au LAMEFIPCrack stability is discussed as affected by their presence in statically-indeterminate beams, frames, rings, etc. loaded into the plastic range.
PARIS, Paul C., Paul C. Paris, PARIS, Paul Croce, PALIN-LUC, Thierry, Thierry Palin-Luc   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Single‐use bioreactors : an overview

, 2019
This chapter aims to give an overview of instrumented single‐use bioreactor (SUB) types that are currently available commercially. Based on the milestones in the development of SUBs, it focuses on the three most often applied types: wave‐mixed, stirred ...
Jossen, Valentin, Eibl-Schindler, Regine, Valentin Jossen, Eibl, Dieter, Dieter Eibl, Regine Eibl   +5 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Challenge of Single-Use Plastic

, 2019
Single-use plastic accounts for about 36% of total plastic production, and represents the largest use of plastic. Because single-use plastic is meant for disposal and because of its volume, it is the most visible and problematic type of plastic pollution.
Dayrit, Fabian M
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Urban Waste Composition Associated with Online Food Delivery in Bangkok, Thailand, with Emphasis on Plastic Waste Management

Urban Science
The rapid growth of online food delivery in urban areas reflects changing consumer lifestyles, but it has also contributed to increasing plastic waste and challenges in waste management.
Yanasinee Suma, Chongrak Polprasert, Numfon Eaktasang   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Plastic Pollution in Agriculture as a Threat to Food Security, the Ecosystem, and the Environment: An Overview

Agronomy
Plastic products in plant production and protection help farmers increase crop production, enhance food quality, and reduce global water use and their environmental footprint.
Imran Ali Lakhiar, Haofang Yan, Jianyun Zhang, Guoqing Wang, Shuaishuai Deng, Rongxuan Bao, Chuan Zhang, Tabinda Naz Syed, Biyu Wang, Rui Zhou, Xuanxuan Wang   +10 more
doaj   +1 more source