Results 131 to 140 of about 12,921,630 (316)

Organoid technology in cancer research

Molecular Biomedicine
Organoid technology has emerged as a transformative tool in cancer research by recapitulating the structural complexity, genomic integrity, and phenotypic heterogeneity of human primary tumors.
Jingjing Zhang, Jian He
doaj   +1 more source

Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana

Plants
Mitochondria are important organelles in eukaryotes and are involved in various metabolic processes. Mitochondrial proteotoxic stress triggers the mitochondrial unfolded protein response (UPRmt) to restore mitochondrial protein homeostasis and maintain ...
Guolong Yu, Zhuoran Huang, Chaocheng Guo, Jiahao Li, Xinyuan Wang, Yudong Wang, Xu Wang   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Mapping NK cell diversity in response to COVID-19 and mRNA vaccination

Scientific Reports
Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood.
Yosuke Kishi, Yu-Chen Liu, Masakazu Ishikawa, Maika Yamashita, Hisatake Matsumoto, Hiroshi Ogura, Shuhei Sakakibara, Daisuke Okuzaki   +7 more
doaj   +1 more source

The hidden mycobiome: emerging role in anticancer immunotherapy

Mycology
As one of the emerging hallmarks, the mycobiome has recently gained significant recognition in cancer research, especially regarding anticancer immunotherapy.
Ze-Chang Peng, Xin-Yu Liu, Qin-Yu Liu, Wan-Qing Lu, Chen-Ze Jin, Tian-Yi Zhang, Ning-Ning Liu   +6 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

MICROBIAL COMMUNITIES: A BIOTECHNOLOGY STUDY WITH SINGLE-CELL SEQUENCING

reservedMicroorganisms are the most abundant life forms on Earth, yet an estimated 90-99% remain uncharacterized due to the limitations of traditional culturing methods in laboratory settings.
ROSSI, MARIA
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

CRISPR screening in single cells

, 2019
The combination of single-cell RNA-seq and CRISPR allows for efficient interrogation of possibly any number of genes, only limited by the sequencing capability. Here we describe the current protocols for CRISPR screening in single cells, from cloning and
Henriksson, Johan,
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source