Results 1 to 10 of about 3,543,075 (195)
Single cell transcriptional analysis reveals novel innate immune cell types [PDF]
PeerJ, 2014 Single-cell analysis has the potential to provide us with a host of new knowledge about biological systems, but it comes with the challenge of correctly interpreting the biological information.
Linda E. Kippner +3 more
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Discovery of alternative polyadenylation dynamics from single cell types [PDF]
Computational and Structural Biotechnology Journal, 2020 Alternative polyadenylation (APA) occurs in the process of mRNA maturation by adding a poly(A) tail at different locations, resulting increased diversity of mRNA isoforms and contributing to the complexity of gene regulatory network.
Congting Ye +2 more
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Molecular phenotyping of plant single cell-types enhances forward genetic analysis [PDF]
Frontiers in Plant Science, 2015 Recent advances in the isolation of single cell-types in plants provides an opportunity to conduct detailed analyses of their molecular characteristics at high resolution.
John eSchiefelbein
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Whole-organism eQTL mapping at cellular resolution with single-cell sequencing
eLife, 2021 Genetic regulation of gene expression underlies variation in disease risk and other complex traits. The effect of expression quantitative trait loci (eQTLs) varies across cell types; however, the complexity of mammalian tissues makes studying cell-type ...
Eyal Ben-David +5 more
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Molecular and spatial profiling of the paraventricular nucleus of the thalamus
eLife, 2023 The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked to cellular differences, the molecular identity and spatial ...
Claire Gao +6 more
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Single Cell RNA Sequencing Reveals Deep Homology of Dental Cell Types Across Vertebrates
Frontiers in Dental Medicine, 2022 Like most mammals, humans replace their teeth once throughout their lives and have limited regenerative capabilities. In contrast, mice continually renew tissues lost due to gnawing through a well characterized population of stem cells on the labial ...
George W. Gruenhagen +4 more
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Quantitative Biology, 2023 Background The precise and efficient analysis of single‐cell transcriptome data provides powerful support for studying the diversity of cell functions at the single‐cell level.
Yuwei Huang +7 more
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Annotating cell types in human single-cell RNA-seq data with CellO
STAR Protocols, 2021 Summary: Cell type annotation is important in the analysis of single-cell RNA-seq data. CellO is a machine-learning-based tool for annotating cells using the Cell Ontology, a rich hierarchy of known cell types.
Matthew N. Bernstein, Colin N. Dewey
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Single‐cell transcriptomics reveals immune response of intestinal cell types to viral infection
Molecular Systems Biology, 2021 Human intestinal epithelial cells form a primary barrier protecting us from pathogens, yet only limited knowledge is available about individual contribution of each cell type to mounting an immune response against infection.
Sergio Triana +12 more
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Single-cell alternative polyadenylation analysis delineates GABAergic neuron types
BMC Biology, 2021 Background Alternative polyadenylation (APA) is emerging as an important mechanism in the post-transcriptional regulation of gene expression across eukaryotic species.
Yang Yang +4 more
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