Results 91 to 100 of about 12,073,927 (302)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Family structure and child maltreatment: Do some family types place children at greater risk? [PDF]
, 2012 Reviewing current research on family structures, this paper aims to assist practitioners and policy-makers who work with children and families to make evidence-informed decisions.
Rhys Price-Robertson
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 1898 This collection consists of a diary, pages from the family scrapbook, and genealogical materials related to the Batchelor family of Little Rock ...
Batchelor family
core +1 more source
Single Mothers, Social Capital, and Work-Family Conflict [PDF]
The purpose of this paper is to examine work-family conflict among low-income, unmarried mothers. I examine how social capital affects work-family conflict and how both social capital and work-family conflict affect employment.
Teresa Ciabattari
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peculiarities of the Personality of Teenagers Raised in Single-Parent Families. Studies and Research
EIRP Proceedings, 2023 The paper presents a series of research on the personality of adolescents raised in single-parent families focused on various aspects of emotional, social, and academic development.
Doinita Popa
doaj
Informes de la Construccion, 1968 El proyecto y construcción de una vivienda unifamiiiar constituye para el arquitecto una experiencia de gran valor, debida tanto al imprescindible diálogo con la propiedad, como a la posibilidad de poder realizar una completa investigación urbanístico-arquitectónica, dado los límites reducidos de la misma.
openaire +1 more source