Results 101 to 110 of about 12,073,927 (302)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Family of Single-Case Experimental Designs
Harvard Data Science Review, 2022 Leonard H. Epstein, Jesse Dallery
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ChildrenGrowing rates of childhood obesity globally create concern for individuals’ health outcomes and demands on health systems. While many policy approaches focus on macro-level interventions, we examine how the type of stability of a family structure might ...
Sadie A. Slighting +6 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Ball Family coat of arms, undated
, 1910 Postcard featuring two coats of arms for the Ball family. The front left section of the postcard features a Ball family coat of arms with a lion on top of a shield with three stars.
Ball family
core +2 more sources
Lesbijki, geje i ich dzieci – różnorodność form rodzinnych
InterAlia, 2013 The article concerns issues related to same-sex parenting. Families made up of lesbians and gays raising children are a challenge for traditional sociological definitions of family.
Dorota Majka-Rostek
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
PREVALENCE AND CORRELATES OF ADJUSTMENT DISORDER IN SINGLE PARENT MOTHERS
Pakistan Armed Forces Medical Journal, 2020 Objective: To investigate prevalence and difference of adjustment disorder in single parent mothers. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Psychology, University of Gujrat, from Jan to Apr 2019.
Iram Naz, Khushnood Fatima, Razia Anjum
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