Results 131 to 140 of about 2,855,386 (298)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

THE USE OF PHYTOTHERAPY IN THE SINGLE HEALTH SYSTEM: INTEGRATIVE REVIEW

open access: yes, 2022
O uso dos fitoterápicos foi reconhecida pela OMS em 1978 para fins de profilaxia, curativa e paliativa, quando recomendou a difusão mundial dos conhecimentos necessários para o seu uso. Segundo ministério da saúde são considerados medicamentos fitoterápicos aqueles obtidos com matérias-primas ativas vegetais.objetivo levantar dados de como é feito o ...
Abreu, Jefferson Oliveira de   +1 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Health Care Provider Prescribing Habits and Barriers to Use of New Type 2 Diabetes Medications: A Single-System Survey Study

open access: yes, 2023
This survey study evaluated type 2 diabetes medication prescribing patterns of health care providers in different specialties and of different professional designations or levels of training at an academic health care system and sought to identify ...
Lahiri, Sharon W, Yaseen, Aseel
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

SINGLE HEALTH SYSTEM (SUS), POLICIES PUBLIC HEALTH AND STOMIA

open access: yes, 2017
This article aims to analyze the issue of intestinal stomies. The aim is to analyze the Brazilian Unified Health System and its relation with the treatment of intestinal stomatal patients: what coverage, what care is taken, what is planned and what guidelines.
openaire   +1 more source

Slovenia: Health System Review

open access: yes, 2021
This analysis of the Slovene health system reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance.
Polin, Katherine   +7 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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